Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
批准号:
nhmrc : 1003326
负责人:
A/Pr Ashley Mansell
金额:
$44.44万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2014-12-31
中文摘要
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英文摘要
Humans first detect the presence of pathogens and respond to them through specific pathways termed innate immune pathways. The proposed research will study proteins that participate in these pathways, in particular their three-dimensional structures and how they interact with each other, to understand how they work together to mount an immune response, and to find ways to modulate this response in infectious diseases as well as chronic inflammatory diseases.
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