Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways

TLR 通路中含有 TIR 结构域的接头信号传导的分子和结构基础

• 批准号: nhmrc : 1003326
• 负责人: A/Pr Ashley Mansell
• 金额: $ 44.44万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-structural-basis-tlr-pathways/108917
• 关键词: Molecular; structural; basis; signalling; TIR

Humans first detect the presence of pathogens and respond to them through specific pathways termed innate immune pathways. The proposed research will study proteins that participate in these pathways, in particular their three-dimensional structures and how they interact with each other, to understand how they work together to mount an immune response, and to find ways to modulate this response in infectious diseases as well as chronic inflammatory diseases.

人类首先检测到病原体的存在，并通过称为先天免疫途径的特定途径对其作出反应。拟议的研究将研究参与这些途径的蛋白质，特别是它们的三维结构以及它们如何相互作用，以了解它们如何共同作用以产生免疫反应，并找到在感染性疾病和慢性炎症性疾病中调节这种反应的方法。