Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
批准号:
nhmrc : GNT1107804
负责人:
A/Pr Ashley Mansell
金额:
$71.2万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 --
中文摘要
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英文摘要
The innate immune system is the first line of defence against pathogens. Inhibitors of innate immune pathways can be developed into therapeutic agents against a number of disorders including chronic inflammatory diseases, such as rheumatoid arthritis. We have discovered a new mechanisms of signaling by a set of key molecules in these pathways, through formation of large assemblies. We will characterize these assemblies and uncover ways to inhibit their formation.
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Regulation of immune responses in the adult testis and male reproductive health
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批准号:nhmrc : 1125149
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财政年份:2017
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负责人:A/Pr Ashley Mansell
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依托单位:
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
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批准号:nhmrc : 1107804
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依托单位:
PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
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依托单位:
PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
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Defining the role of the novel gene MUL1 in antiviral innate immunity
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Targeting renal and vascular inflammation in hypertension
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依托单位:
Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
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批准号:nhmrc : 1003326
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项目类别:Project Grants
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财政年份:2011
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依托单位:
Toll-like receptor and MyD88 signalling in the testis
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批准号:nhmrc : 1011115
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依托单位:
H1N1 Development of a signature for early responses to influenza strains that determine -correlate with severity of infe
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批准号:nhmrc : 606976
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财政年份:2009
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负责人:A/Pr Ashley Mansell
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依托单位:
Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer
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批准号:nhmrc : 490956
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项目类别:NHMRC Project Grants
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资助金额:$11.66万
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财政年份:2008
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依托单位:
Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)
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资助金额:$36.16万
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负责人:A/Pr Ashley Mansell
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依托单位:
Negative regulation and immune subversion of Toll-like receptor signaling pathways
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批准号:nhmrc : 465116
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项目类别:Career Development Fellowships
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资助金额:$31.41万
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财政年份:2007
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负责人:A/Pr Ashley Mansell
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依托单位:
The role of Mal in Toll-like receptor signal transduction of the pro-inflammatory response.
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项目类别:NHMRC Project Grants
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财政年份:2005
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负责人:A/Pr Ashley Mansell
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依托单位:
国内基金
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