INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
批准号:
nhmrc : 1143674
负责人:
A/Pr Ashley Mansell
金额:
$67.84万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Chronic kidney disease (CKD) is a major health problem. There is no cure for CKD and current therapies merely slow its progression. Thus for many patients, dialysis or kidney transplant is an inevitable outcome. We have evidence that a protein called interleukin-18 (IL-18) is a key mediator of kidney damage in CKD. Here we will explore how IL-18 causes kidney damage and whether IL-18 may be used as a diagnostic for early detection of CKD, and a target for more effective therapies to treat CKD.
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INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
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批准号:nhmrc : GNT1143674
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项目类别:Project Grants
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资助金额:$100.33万
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财政年份:2018
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负责人:A/Pr Ashley Mansell
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依托单位:
Regulation of immune responses in the adult testis and male reproductive health
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批准号:nhmrc : GNT1125149
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项目类别:Project Grants
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资助金额:$63.79万
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财政年份:2017
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负责人:A/Pr Ashley Mansell
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依托单位:
Regulation of immune responses in the adult testis and male reproductive health
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批准号:nhmrc : 1125149
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项目类别:Project Grants
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资助金额:$43.53万
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财政年份:2017
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负责人:A/Pr Ashley Mansell
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依托单位:
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
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批准号:nhmrc : GNT1107804
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项目类别:Project Grants
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资助金额:$71.2万
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财政年份:2016
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负责人:A/Pr Ashley Mansell
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依托单位:
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
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批准号:nhmrc : 1107804
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项目类别:Project Grants
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资助金额:$48.83万
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财政年份:2016
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负责人:A/Pr Ashley Mansell
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依托单位:
PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
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批准号:nhmrc : 1079924
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项目类别:Project Grants
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资助金额:$44.27万
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财政年份:2015
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负责人:A/Pr Ashley Mansell
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依托单位:
PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
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批准号:nhmrc : GNT1079924
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项目类别:Project Grants
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资助金额:$64.31万
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财政年份:2015
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负责人:A/Pr Ashley Mansell
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依托单位:
Defining the role of the novel gene MUL1 in antiviral innate immunity
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批准号:nhmrc : 1062977
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项目类别:Project Grants
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资助金额:$34.11万
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财政年份:2014
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负责人:A/Pr Ashley Mansell
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依托单位:
Targeting renal and vascular inflammation in hypertension
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批准号:nhmrc : 1062721
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项目类别:Project Grants
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资助金额:$52.12万
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财政年份:2014
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负责人:A/Pr Ashley Mansell
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依托单位:
Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
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批准号:nhmrc : 1003326
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项目类别:Project Grants
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资助金额:$44.44万
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财政年份:2011
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负责人:A/Pr Ashley Mansell
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依托单位:
Toll-like receptor and MyD88 signalling in the testis
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批准号:nhmrc : 1011115
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项目类别:NHMRC Project Grants
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资助金额:$33.23万
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财政年份:2011
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负责人:A/Pr Ashley Mansell
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依托单位:
H1N1 Development of a signature for early responses to influenza strains that determine -correlate with severity of infe
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批准号:nhmrc : 606976
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项目类别:NHMRC Strategic Awards
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资助金额:$21.29万
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财政年份:2009
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负责人:A/Pr Ashley Mansell
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依托单位:
Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer
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批准号:nhmrc : 490956
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项目类别:NHMRC Project Grants
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资助金额:$11.66万
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财政年份:2008
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负责人:A/Pr Ashley Mansell
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依托单位:
Suppression of Immune Toll-like receptor (TLR) signaling by Hepatitis B e Antigen (HBeAg)
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批准号:nhmrc : 491017
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项目类别:NHMRC Project Grants
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资助金额:$36.16万
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财政年份:2008
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负责人:A/Pr Ashley Mansell
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依托单位:
Negative regulation and immune subversion of Toll-like receptor signaling pathways
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批准号:nhmrc : 465116
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项目类别:Career Development Fellowships
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资助金额:$31.41万
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财政年份:2007
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负责人:A/Pr Ashley Mansell
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依托单位:
The role of Mal in Toll-like receptor signal transduction of the pro-inflammatory response.
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批准号:nhmrc : 334023
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项目类别:NHMRC Project Grants
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资助金额:$31.51万
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财政年份:2005
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负责人:A/Pr Ashley Mansell
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依托单位:
国内基金
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