Targeting renal and vascular inflammation in hypertension

针对高血压患者的肾脏和血管炎症

• 批准号: nhmrc : 1062721
• 负责人: A/Pr Ashley Mansell
• 金额: $ 52.12万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-renal-vascular-inflammation-hypertension/455016
• 关键词: Targeting; renal; vascular; inflammation; hypertension

Inflammation is a hallmark of high blood pressure (A.K.A. hypertension) and underlies clinical complications of the condition such as kidney failure and blood vessel disease. This project will investigate whether a recently described signaling complex termed the 'inflammasome' is a trigger of inflammation in hypertension in the hope of identifying it as a target for new drugs that are more effective in the treatment of hypertension and its complications.

炎症是高血压(又名高血压)的一个特征，也是这种疾病的临床并发症，如肾衰竭和血管疾病的基础。该项目将调查最近描述的被称为“炎症体”的信号复合体是否是高血压炎症的触发因素，以期将其确定为治疗高血压及其并发症更有效的新药的靶点。