Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways

Toll 样受体途径中高阶组装信号传导的表征和抑制

• 批准号: nhmrc : 1107804
• 负责人: A/Pr Ashley Mansell
• 金额: $ 48.83万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-inhibition-higher-receptor-pathways/663003
• 关键词: Characterization; inhibition; higher; order; assembly

The innate immune system is the first line of defence against pathogens. Inhibitors of innate immune pathways can be developed into therapeutic agents against a number of disorders including chronic inflammatory diseases, such as rheumatoid arthritis. We have discovered a new mechanisms of signaling by a set of key molecules in these pathways, through formation of large assemblies. We will characterize these assemblies and uncover ways to inhibit their formation.

先天免疫系统是抵御病原体的第一道防线。先天免疫途径的抑制剂可以开发成针对许多疾病的治疗剂，包括慢性炎症性疾病，例如类风湿性关节炎。我们发现了这些途径中一组关键分子通过形成大型组装体来发出信号的新机制。我们将描述这些集合的特征，并找出抑制其形成的方法。