Syntheis and biofunctionalization of degradable ester-amide biomaterials for tissue engineering applications

用于组织工程应用的可降解酯酰胺生物材料的合成和生物功能化

• 批准号: 288130-2008
• 负责人: Mequanint, Kibret
• 金额: $ 1.61万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=427208
• 关键词: Syntheis; biofunctionalization; degradable; ester; amide

THE NATURE OF THE WORK TO BE DONE: Tissue engineering holds great promise as an alternative strategy to current treatment modalities of diseased or otherwise failed tissues. Most strategies of tissue engineering rely on porous 3-dimensional scaffolds as templates to guide tissue regeneration. These scaffolds play the role of a synthetic extracellular matrix that facilitates the organization of cells into a 3-dimensional architecture and address the mechanical stimuli that rule the growth and formation of the desired tissue. The work proposed here involves the design of novel scaffolding materials from naturally occurring amino acids.

待完成工作的性质：组织工程作为目前治疗患病或其他失败组织的替代策略具有很大的前景。组织工程的大多数策略依赖于多孔三维支架作为模板来引导组织再生。这些支架起到合成细胞外基质的作用，其促进细胞组织成三维结构，并解决控制所需组织的生长和形成的机械刺激。这里提出的工作涉及从天然存在的氨基酸设计新的支架材料。