Novel asymmetric synthesis of helically and planar chiral molecules

在过去的几十年里，不对称催化科学取得了重大进展。然而，随着大自然不断为有机化学家提供新的、迷人的化学结构，它也向我们提出了新的挑战。这些新的挑战需要更加通用、实用、环保和强大的技术。因此，不对称合成不断发展，现有的合成方法经常被更有效的方法所取代。该研究计划的具体目标是开发具有螺旋和平面手性的分子的立体选择性合成的新方法。具有这种独特化学性质的分子具有相当重要的意义。这些分子在许多科学学科和许多工业应用（制药，农用化学品，生物学，生物化学，食品科学等）中都有发现。考虑到今天对对映体纯化合物的需求，我们提出的研究重点是开发新的催化策略来构建这些分子。

During the last few decades the science of asymmetric catalysis has experienced significant advances. However, as Nature continues to supply organic chemists with new and fascinating chemical structures, it also presents us with new challenges. These new challenges demand technologies that are ever more general, practical, environmentally friendly and powerful. Consequently, asymmetric synthesis continues to evolve and existing synthetic methods are often replaced as more effective methods are developed. The specific goal of the research program is to develop new methods for the stereoselective synthesis of molecules possessing helical and planar chirality. The molecules that possess this unique chemical property are of considerable importance. These molecules are found across many scientific disciplines and in many industrial applications (pharmaceuticals, agrochemicals, biology, biochemistry, food sciences, etc.). Considering today's demand for enantiomerically pure compounds, our proposed research focuses on developing new catalytic strategies to construct these molecules.