Understanding RAB39B-mediated Parkinson's disease

了解 RAB39B 介导的帕金森病

• 批准号: nhmrc : 1144724
• 负责人: A/Pr David Finkelstein
• 金额: $ 48.99万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-rab39b-mediated-parkinsons-disease/1320253
• 关键词: Understanding; RAB39B; mediated; Parkinson; disease

Parkinson’s disease (PD) is a complex neurological condition affecting 100,000 Australians. The primary clinical features of PD result from the selective loss of a specific type of neuron. It is currently unclear why these neurons are preferentially lost. We have identified a novel gene that causes early onset PD. This study will characterise the gene and determine the underlying disease mechanism. These studies will enable the development of novel therapies for treating PD.

帕金森病（PD）是一种复杂的神经系统疾病，影响着10万澳大利亚人。PD的主要临床特征是由于特定类型神经元的选择性丧失。目前尚不清楚为什么这些神经元优先丢失。我们已经确定了一个新的基因，导致早发性PD。这项研究将验证该基因并确定潜在的疾病机制。这些研究将有助于开发治疗PD的新疗法。