Regulation of regeneration of Dopaminergic neurones in the substantia nigra

黑质多巴胺能神经元再生的调节

• 批准号: nhmrc : 194411
• 负责人: A/Pr David Finkelstein
• 金额: $ 7.73万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-regeneration-dopaminergic-substantia-nigra/95205
• 关键词: Regulation; regeneration; Dopaminergic; neurones; substantia

Parkinson's Disease (PD) results from the progressive loss of brain cells in the part of the brain called substantia nigra. These brain cells contain a chemical called Dopamine (DA). The symptoms of Parkinson's disease arise when about 80% these DA neurones are lost suggesting that some form of compensation must occur up to this point. In previous studies we have demonstrated that one mechanism for this compensation is through sprouting or branching of the remaining neurones. We have preliminary evidence about the way this is sprouting and regeneration is controlled. The aim of this grant is to explore in detail the mechanisms whereby sprouting is induced and regulated. The significance of this study is that it may provide insights into the way in which regulation of regeneration of the nervous system is controlled. It has specific applications to therapies for Parkinson's disease.

帕金森病 (PD) 是由于大脑中称为黑质的部分脑细胞逐渐丧失所致。这些脑细胞含有一种叫做多巴胺（DA）的化学物质。当大约 80% 的 DA 神经元丢失时，帕金森病的症状就会出现，这表明在此之前必须进行某种形式的补偿。在之前的研究中，我们已经证明这种补偿的一种机制是通过剩余神经元的发芽或分支。我们有关于其发芽和再生控制方式的初步证据。这笔赠款的目的是详细探索诱导和调节发芽的机制。这项研究的意义在于，它可以为神经系统再生调节的控制方式提供见解。它在帕金森病的治疗中具有特定的应用。