IRON EXPORT PROTEIN FAILURE IN PARKINSONISM AND DEMENTIA

帕金森症和痴呆症中的铁输出蛋白失败

• 批准号: nhmrc : 1044542
• 负责人: A/Pr David Finkelstein
• 金额: $ 56.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/iron-export-protein-parkinsonism-dementia/111670
• 关键词: IRON; EXPORT; PROTEIN; FAILURE; PARKINSONISM

We recently discovered a novel relationship between the Alzheimer’s amyloid precursor protein (APP) and tau, and that both proteins play a role in regulating iron levels in the brain. We predict that a loss or multiple failures in these iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of diseases with dementia such as Alzheimer’s and Parkinson’s diseases. We hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.

我们最近发现了阿尔茨海默氏症淀粉样前体蛋白（APP）和tau之间的一种新关系，这两种蛋白质都在调节大脑中的铁水平方面发挥作用。我们预测，这些铁调节系统的丢失或多次失败可能会促进大脑中有毒铁的积累，导致痴呆症如阿尔茨海默病和帕金森病的发展。我们希望更好地了解它们的作用机制，并提出这一途径是治疗干预的目标。