Identifying the mechanisms of action of a novel 8-hydroxy quinazolinone in models of Parkinson's disease

确定新型 8-羟基喹唑啉酮在帕金森病模型中的作用机制

• 批准号: nhmrc : 1043992
• 负责人: A/Pr David Finkelstein
• 金额: $ 46.07万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-mechanisms-action-parkinsons-disease/111621
• 关键词: Identifying; mechanisms; action; novel; hydroxy

By the time symptoms of Parkinson's disease (PD) appear, 60-70% of the cells in a crucial part of the brain called the substantia nigra have been destroyed and within a few years of diagnosis, most of the remaining cells have died. This project investigates the causes of this cell loss and a how a new class of compounds could interrupts the process. Success in achieving the aims of this proposal will add to our knowledge of the causes of neuronal death in PD

当帕金森氏症(PD)的症状出现时，大脑中称为黑质的关键部分的60%-70%的细胞已经被破坏，在诊断的几年内，大多数剩余的细胞已经死亡。这个项目调查了这种细胞丢失的原因，以及一种新的化合物类如何中断这一过程。如果能成功地实现这项提案的目标，将增加我们对帕金森病神经元死亡原因的了解