Developing a novel therapy for Parkinsons Disease

开发帕金森病的新疗法

• 批准号: nhmrc : 509286
• 负责人: A/Pr David Finkelstein
• 金额: $ 33.97万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/developing-novel-therapy-parkinsons-disease/97630
• 关键词: Developing; novel; therapy; Parkinsons; Disease

By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a large proportion (60-70%) of the cells in a specific part of the brain have been destroyed. This degeneration progresses until, within a few years, most of the cells have died. This project investigates the mechanisms involved in the continued death of cells and a possible new therapy that interrupts the progression. If the aims of this proposal are met, the drug could rapidly go to clinical trial.

当患者在诊所首次表现出帕金森病的症状时，大脑特定部位的大部分细胞（60-70%）已经被破坏。这种退化会持续下去，直到几年内大部分细胞死亡。该项目研究了细胞持续死亡的机制，以及一种可能阻断这一进程的新疗法。如果这项提议的目标得以实现，这种药物将很快进入临床试验阶段。