Mechanism of action of a quinazolinone in models of PD

喹唑啉酮在 PD 模型中的作用机制

• 批准号: nhmrc : GNT1043992
• 负责人: A/Pr David Finkelstein
• 金额: $ 66.75万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-action-quinazolinone-models-pd/1344441
• 关键词: Mechanism; action; quinazolinone; models; PD

By the time symptoms of Parkinson's disease (PD) appear, 60-70% of the cells in a crucial part of the brain called the substantia nigra have been destroyed and within a few years of diagnosis, most of the remaining cells have died. This project investigates the causes of this cell loss and a how a new class of compounds could interrupts the process. Success in achieving the aims of this proposal will add to our knowledge of the causes of neuronal death in PD

当帕金森病（PD）的症状出现时，大脑中称为黑质的关键部位的60-70%的细胞已经被破坏，并且在诊断后的几年内，大多数剩余的细胞已经死亡。该项目调查了这种细胞损失的原因以及一类新化合物如何中断这一过程。成功地实现这一建议的目的将增加我们对帕金森病神经元死亡原因的认识