Copper pathways are altered in Parkinson’s disease: Implications for cell vulnerability
Copper pathways are altered in Parkinson’s disease: Implications for cell vulnerability
批准号:
nhmrc : 1003903
负责人:
A/Pr David Finkelstein
金额:
$22.76万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2014-12-31
中文摘要
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英文摘要
The cause of brain cell death in Parkinson’s disease is unknown but we have shown that copper levels are reduced in the vulnerable brain regions in this disorder. As copper is vital for the normal function of key brain proteins we suggest that reduced copper contributes to cell damage in vulnerable brain regions. This project investigates why brain copper levels are reduced in the Parkinson’s disease brain and the consequences of this change for brain cell function and survival.
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Understanding RAB39B-mediated Parkinson's disease
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批准号:nhmrc : GNT1144724
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项目类别:Project Grants
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资助金额:$72.46万
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财政年份:2018
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负责人:A/Pr David Finkelstein
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依托单位:
Unravelling the neuropathological basis of the gastrointestinal manifestations of Parkinson’s Disease
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批准号:nhmrc : 1145686
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项目类别:Project Grants
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资助金额:$55.64万
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财政年份:2018
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负责人:A/Pr David Finkelstein
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依托单位:
Understanding RAB39B-mediated Parkinson's disease
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批准号:nhmrc : 1144724
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项目类别:Project Grants
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资助金额:$48.99万
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财政年份:2018
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负责人:A/Pr David Finkelstein
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依托单位:
Unravelling the neuropathological basis of the gastrointestinal manifestations of Parkinson’s Disease
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批准号:nhmrc : GNT1145686
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项目类别:Project Grants
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资助金额:$82.3万
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财政年份:2018
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负责人:A/Pr David Finkelstein
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依托单位:
Mechanism of action of a quinazolinone in models of PD
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批准号:nhmrc : GNT1043992
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项目类别:Project Grants
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资助金额:$66.75万
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财政年份:2013
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负责人:A/Pr David Finkelstein
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依托单位:
Identifying the mechanisms of action of a novel 8-hydroxy quinazolinone in models of Parkinson's disease
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批准号:nhmrc : 1043992
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项目类别:Project Grants
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资助金额:$46.07万
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财政年份:2013
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负责人:A/Pr David Finkelstein
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依托单位:
IRON EXPORT PROTEIN FAILURE IN PARKINSONISM AND DEMENTIA
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批准号:nhmrc : 1044542
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项目类别:Project Grants
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资助金额:$56.23万
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财政年份:2013
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负责人:A/Pr David Finkelstein
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依托单位:
The modulation of metals to improve the cognitive and pathological features of Alzheimers disease
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批准号:nhmrc : 566853
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项目类别:NHMRC Project Grants
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资助金额:$29.09万
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财政年份:2009
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负责人:A/Pr David Finkelstein
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依托单位:
Developing a novel therapy for Parkinsons Disease
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批准号:nhmrc : 509286
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项目类别:NHMRC Project Grants
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资助金额:$33.97万
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财政年份:2008
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负责人:A/Pr David Finkelstein
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依托单位:
Regulation of regeneration of Dopaminergic neurones in the substantia nigra
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批准号:nhmrc : 194411
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项目类别:NHMRC Project Grants
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资助金额:$7.73万
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财政年份:2002
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负责人:A/Pr David Finkelstein
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依托单位:
The Output Pathways of the Basal Ganglia
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批准号:nhmrc : 143553
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项目类别:NHMRC Project Grants
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资助金额:$17.12万
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财政年份:2001
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负责人:A/Pr David Finkelstein
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依托单位:
国内基金
海外基金
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