Copper pathways are altered in Parkinson’s disease: Implications for cell vulnerability

帕金森病中的铜通路发生改变：对细胞脆弱性的影响

• 批准号: nhmrc : 1003903
• 负责人: A/Pr David Finkelstein
• 金额: $ 22.76万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/copper-pathways-altered-cell-vulnerability/108979
• 关键词: Copper; pathways; altered; Parkinson; disease

The cause of brain cell death in Parkinson’s disease is unknown but we have shown that copper levels are reduced in the vulnerable brain regions in this disorder. As copper is vital for the normal function of key brain proteins we suggest that reduced copper contributes to cell damage in vulnerable brain regions. This project investigates why brain copper levels are reduced in the Parkinson’s disease brain and the consequences of this change for brain cell function and survival.

帕金森氏症中脑细胞死亡的原因尚不清楚，但我们已经证明，在这种疾病中，大脑脆弱区域的铜水平降低。由于铜对关键脑蛋白的正常功能至关重要，我们认为铜的减少会导致大脑脆弱区域的细胞损伤。该项目调查了帕金森病患者大脑中铜含量降低的原因，以及这种变化对脑细胞功能和生存的影响。