The Output Pathways of the Basal Ganglia

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Parkinson's Disease is caused by injury to a group of brain cells called the Basal Ganglia. Our current ideas about how this part of the brain works is dominated by a well know theory. This theory requires that the output pathway of the basal ganglia to have a negative or inhibitory influence on its target. However there are numerous reasons why this would be unlikely, including some recent evidence from experiments in our laboratory. The purpose of this study is to undertake an extensive re examination of the output paths of the Basal Ganglia. If our suspicions are correct, it will lead to a review of the whole way in which we think the Basal Ganglia works.