Market assessment for a novel instrument based on surface plasmon resonance

有必要进行市场评估，以确定优先事项，以确定开发新型表面等离子体共振(SPR)仪器的下一步步骤。我们的SPR样机无需标记，价格低廉，具有高灵敏度和高选择性，适用于原油生物体液中生物标志物的分析。这些成果是基于鸽子棱镜的新型SPR仪器设计，以及基于微图案化金膜和防污多肽表面化学的传感芯片技术的结果。我们开发的原型是便携的，因此，适合于测量点应用，如医疗保健点诊断或污染物或病原体的现场检测。我们的便携式SPR仪器的分辨率可与更昂贵的实验室SPR仪器相媲美。与其他商用传感技术相比，我们的传感芯片技术将灵敏度提高了3倍以上，从而减少了误差。此外，我们的多肽单层可防止传感芯片结垢，从而防止假阳性反应，这对于护理点式生物医学应用是必要的。

A market assessment is necessary to establish the priorities that will dictate the next steps for the development of a novel Surface Plasmon Resonance (SPR) instrument. Our prototype SPR device is label-free, inexpensive, exhibits high sensitivity and selectivity and is suited for the analysis of biomarkers in crude biofluids. These achievements were the consequence of a novel SPR instrument design based on a dove prism, and a sensing chip technology based on micropatterned gold films and anti-fouling peptide surface chemistry. The prototype we have developed is portable and thus, is suited for point-of-measurement applications such as point-of-care diagnostics or on-site detection of contaminants or pathogens. The resolution of our portable SPR instrument rivals the one obtained with more expensive lab-based SPR instruments. Our sensing chip technology improves the sensitivity by more than a factor of 3 relative to other commercial sensing technologies, reducing error. In addition, our peptide monolayers prevent fouling of the sensing chip, and thus, false positive responses, which is necessary for point-of-care biomedical applications.