The role of a novel kinase-regulated SUMO conjugation protein process on estrogen receptor function and gene transcription

一种新型激酶调节的 SUMO 缀合蛋白过程对雌激素受体功能和基因转录的作用

• 批准号: 311761-2012
• 负责人: Tremblay, André
• 金额: $ 1.89万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=505710
• 关键词: role; novel; kinase; regulated; SUMO

Recently, the identification of SUMOylation, the process by which SUMO, a small ubiquitin-like modifier, is covalently linked to target proteins, has emerged as a new protein modification that regulates gene transcription. The functional consequences of protein SUMOylation are not well understood, but it raises interesting possibility that SUMOylation may serve as a novel mechanism by which hormonal signaling pathways regulate transcription.

最近，SUMO修饰（一个小的泛素样修饰物SUMO与靶蛋白共价连接的过程）的鉴定已经成为一种新的调节基因转录的蛋白质修饰。蛋白质SUMOylation的功能后果尚不清楚，但它提出了一种有趣的可能性，即SUMOylation可能作为激素信号通路调节转录的新机制。