The role of a novel SUMO conjugation process on estrogen receptor function and gene transcription

新型 SUMO 缀合过程对雌激素受体功能和基因转录的作用

• 批准号: 311761-2013
• 负责人: Tremblay, André
• 金额: $ 2.62万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548494
• 关键词: role; novel; SUMO; conjugation; process

Recently, the identification of SUMOylation, the process by which a small modifier protein called SUMO is attached to target proteins, has emerged as a novel mechanism that regulates gene expression. However, the functional consequences of SUMOylation are not very well understood and our goal is to better understand its role in terms of hormone receptors response.

最近，SUMO化的鉴定，即一种称为SUMO的小修饰蛋白与靶蛋白连接的过程，已成为一种调节基因表达的新机制。然而，SUMO化的功能性后果还不是很清楚，我们的目标是更好地了解它在激素受体反应方面的作用。