Self-assembly of DNA and biologically enabled polymers

DNA 和生物聚合物的自组装

• 批准号: 217563-2008
• 负责人: Sleiman, Hanadi
• 金额: $ 4.01万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2012
• 资助国家: 加拿大
• 起止时间: 2012-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=514218
• 关键词: Self; assembly; DNA; biologically; enabled

Our research group focuses on the development of DNA-mediated methods to pattern materials with high precision on the nanometer scale. Towards this goal, we have examined the use of synthetic molecules to direct DNA self-assembly. This approach has resulted in a unique range of previously unreported materials, from discrete assemblies of gold nanoparticles and transition metals with fine positioning of each component, to 3D-DNA capsules of any geometry and size, to new forms of DNA in which multiple strands (rather than two) come together. In addition, we have shown, for the first time, the use of small molecules to switch and modify the structure of these assemblies in real-time, and to change the outcome of the self-assembly.

我们的研究小组专注于开发DNA介导的方法，以在纳米尺度上实现高精度的材料图案化。 为了实现这一目标，我们已经研究了使用合成分子来指导DNA自组装。 这种方法产生了一系列以前未报道的独特材料，从金纳米颗粒和过渡金属的离散组件，每个组件的精细定位，到任何几何形状和大小的3D-DNA胶囊，再到多股（而不是两股）聚集在一起的新形式的DNA。 此外，我们还首次展示了使用小分子实时切换和修改这些组件的结构，并改变自组装的结果。