Carbohydrates, enzymes and natural products

碳水化合物、酶和天然产物

• 批准号: RGPIN-2015-03876
• 负责人: Jakeman, David
• 金额: $ 3.28万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589440
• 关键词: Carbohydrates; enzymes; natural; products

The Jakeman discovery grant program will make fundamental scientific discoveries in biological chemistry. These discoveries will have a significant impact on understanding the mechanisms of enzymes, Nature’s predominant catalysts. It focuses upon enzymes that catalyze reactions of ubiquitous importance within the natural sciences. It will provide insight into new ways to inhibit specific enzyme classes or to generate greater substrate specificity. Some of these enzymes are responsible for the production of secondary metabolites, small molecules that have unprecedented capacity to interact with the natural world. Many have been harvested and developed as drugs or technological tools. Our studies on the enzymes include paradigm shifting methods to rationally alter the structures, and hence confer different physicochemical properties on natural products.

雅克曼发现资助计划将在生物化学方面做出基础性的科学发现。这些发现将对理解酶的机制产生重大影响，酶是自然界的主要催化剂。它的重点是催化自然科学中普遍存在的重要反应的酶。它将提供对抑制特定酶类或产生更大底物专一性的新方法的洞察。其中一些酶负责产生次生代谢物，这些小分子具有与自然界相互作用的前所未有的能力。其中许多是作为药物或技术工具收获和开发的。我们对酶的研究包括范式转换方法，以合理地改变结构，从而赋予天然产品不同的物理化学性质。