Carbohydrates, enzymes and natural products

碳水化合物、酶和天然产物

• 批准号: RGPIN-2015-03876
• 负责人: Jakeman, David
• 金额: $ 3.28万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=688872
• 关键词: Carbohydrates; enzymes; natural; products

The Jakeman discovery grant program will make fundamental scientific discoveries in biological chemistry. These discoveries will have a significant impact on understanding the mechanisms of enzymes, Nature's predominant catalysts. It focuses upon enzymes that catalyze reactions of ubiquitous importance within the natural sciences. It will provide insight into new ways to inhibit specific enzyme classes or to generate greater substrate specificity. Some of these enzymes are responsible for the production of secondary metabolites, small molecules that have unprecedented capacity to interact with the natural world. Many have been harvested and developed as drugs or technological tools. Our studies on the enzymes include paradigm shifting methods to rationally alter the structures, and hence confer different physicochemical properties on natural products.******The program of research will provide an excellent training environment for undergraduate, graduate (MSc and PhD) and PDF trainees. Trainees will develop skills in multiple areas including: carbohydrate synthesis, enzymology, molecular genetics, and natural products isolation and structure elucidation. Trainees will experience an environment where daily guidance, discussion and problem-solving are of paramount importance. They will be provided with timely encouragement and feedback on written and oral research results to ensure that they will achieve their maximum potential. Collaboration between trainees at different levels of training helps develop communication skills and improve problem-solving. The trainees will learn research skills relevant to the real-world to provide them with optimum opportunities upon completion of training.******Jakeman is a mid-career researcher with an excellent track record of publishing novel research findings in high quality academic journals. He has an extensive network of collaborators within Canada and worldwide with whom he has published. Trainees from his research program have been highly successful as scientists, in industry and academia within Canada and elsewhere.**

杰克曼发现资助计划将在生物化学方面进行基础科学发现。这些发现将对理解酶的机制产生重大影响，酶是自然界主要的催化剂。它着重于酶，催化的反应在自然科学中无处不在的重要性。它将为抑制特定酶类或产生更大底物特异性的新方法提供见解。其中一些酶负责产生次级代谢物，这些小分子具有与自然界相互作用的前所未有的能力。许多已经被收获并开发成药物或技术工具。我们对酶的研究包括范式转换方法，以合理地改变结构，从而赋予天然产物不同的物理化学性质。******研究计划将为本科生，研究生（硕士和博士）和PDF学员提供良好的培训环境。学员将在多个领域发展技能，包括：碳水化合物合成、酶学、分子遗传学、天然产物分离和结构解析。学员将体验到一个日常指导、讨论和解决问题至关重要的环境。我们会及时鼓励他们，并就书面和口头研究结果给予反馈，以确保他们发挥最大潜能。在不同层次的培训中，学员之间的合作有助于培养沟通技巧和提高解决问题的能力。学员将学习与现实世界相关的研究技能，以便在完成培训后为他们提供最佳机会。******Jakeman是一名职业生涯中期的研究人员，在高质量的学术期刊上发表了新颖的研究成果。他在加拿大和世界各地拥有广泛的合作者网络，并与他们一起发表了作品。他的研究项目的学员在加拿大和其他地方的工业界和学术界都取得了非常成功的科学家