Carbohydrates, enzymes and natural products

碳水化合物、酶和天然产物

基本信息

  • 批准号:
    RGPIN-2020-03893
  • 负责人:
  • 金额:
    $ 2.62万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2020
  • 资助国家:
    加拿大
  • 起止时间:
    2020-01-01 至 2021-12-31
  • 项目状态:
    已结题

项目摘要

The Jakeman NSERC Discovery research grant program will make fundamental scientific discoveries in biological chemistry. These discoveries will have a significant impact on understanding the mechanisms of enzymes, Nature's predominant catalysts. It focuses upon enzymes that catalyze reactions of ubiquitous importance within the natural sciences. It will provide insight into new ways to inhibit specific enzyme classes or to generate greater substrate specificity. Some of these enzymes are responsible for the production of secondary metabolites, small molecules that have unprecedented capacity to interact with the natural world. Our studies on the enzymes include paradigm shifting methods to rationally alter the structures, and hence confer different physicochemical properties, of natural products. The program of research will provide an excellent training environment for undergraduate, graduate (MSc and PhD) and PDF trainees. Trainees will develop skills in multiple areas including: carbohydrate synthesis, enzymology, and natural products isolation and structure elucidation. Trainees will be part of a respectful learning environment where daily guidance, discussion and problem-solving are of paramount importance. They will be provided with timely encouragement and feedback on written and oral research results to ensure that they achieve their maximum potential. Collaboration between trainees at different levels of training will strengthen communication skills and improve problem-solving. Trainees will learn research skills relevant to the real-world to provide them with optimum opportunities upon completion of training. Trainees will continue to participate in workshops emphasising the charter of rights with topics including equity, diversity and inclusion (EDI), GBA+, gender bias, and unconscious bias to maximize the training environment and better prepare them for the workplace. Over the past NSERC funding period, the Jakeman laboratory has trained 9 undergraduates, 4 MSc, 3 PhD students and 6 PDFs, including three undergraduate visiting students from Europe. Trainees are productive in the Jakeman group: 34 manuscripts have been authored by them. The positions they secure upon departure are also excellent. Two former PhD trainees are currently PDFs. One is at the University of Michigan, and another at UBC transitioning to a research scientist position with Codexis, San Francisco. There she will apply Chemistry Nobel Laureate Francis Arnold's directed evolution to engineer protein biocatalysts. Two former MSc students are pursuing PhD research at Ottawa and McGill. Executives in Canadian industry are also impressed by trainees from the Jakeman lab with the most recent PDF being recruited by Intellisyn (Montreal).
Jakeman NSERC Discovery研究资助计划将在生物化学领域进行基础科学发现。这些发现将对理解酶的机制产生重大影响,酶是自然界的主要催化剂。它集中在酶催化反应的普遍存在的重要性,在自然科学。它将提供新的方法来抑制特定的酶类或产生更大的底物特异性的见解。其中一些酶负责产生次级代谢产物,这些小分子具有与自然界相互作用的前所未有的能力。我们对酶的研究包括范式转换方法,以合理地改变结构,从而赋予不同的物理化学性质,天然产物。 研究计划将为本科生,研究生(硕士和博士)和PDF学员提供良好的培训环境。学员将在多个领域发展技能,包括:碳水化合物合成,酶学,天然产物分离和结构解析。学员将成为一个相互尊重的学习环境的一部分,在这个环境中,日常指导、讨论和解决问题至关重要。他们将及时获得书面和口头研究结果的鼓励和反馈,以确保他们发挥最大潜力。不同级别培训的学员之间的合作将加强沟通技能,改善解决问题的能力。学员将学习与现实世界相关的研究技能,以便在完成培训后为他们提供最佳机会。学员将继续参加强调权利宪章的研讨会,主题包括公平,多样性和包容性(EDI),GBA+,性别偏见和无意识偏见,以最大限度地提高培训环境,并为工作场所做好准备。 在过去的NSERC资助期间,Jakeman实验室培养了9名本科生,4名硕士,3名博士生和6名PDF,其中包括3名来自欧洲的本科访问生。杰克曼小组的受训人员富有成效:他们撰写了34篇手稿。他们离开时的位置也很好。两名前博士生目前是PDF。一个是在密歇根大学,另一个在UBC过渡到一个研究科学家的立场与Codexis,旧金山弗朗西斯科。在那里,她将应用化学诺贝尔奖得主弗朗西斯阿诺德的定向进化工程蛋白质生物催化剂。两名前硕士生正在渥太华和麦吉尔攻读博士研究。加拿大工业界的高管们也对来自Jakeman实验室的学员印象深刻,最近的PDF被Intellisyn(蒙特利尔)招募。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jakeman, David其他文献

Jakeman, David的其他文献

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{{ truncateString('Jakeman, David', 18)}}的其他基金

Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2020-03893
  • 财政年份:
    2022
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2020-03893
  • 财政年份:
    2021
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
To inform drug design for COVID-19: Computational determination of interactions between COVID-19 gene products and structurally diverse natural products and clinical drugs
为 COVID-19 的药物设计提供信息:计算确定 COVID-19 基因产物与结构多样的天然产物和临床药物之间的相互作用
  • 批准号:
    550135-2020
  • 财政年份:
    2020
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Alliance Grants
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2019
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2018
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2017
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2016
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Chemoenzymatic methods to prepare N-glucuronides for use in drug discovery
化学酶法制备用于药物发现的 N-葡萄糖苷酸
  • 批准号:
    492417-2015
  • 财政年份:
    2016
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Engage Grants Program
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2015
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Engineering enzymes for natural product glycodiversification
用于天然产物糖多样化的工程酶
  • 批准号:
    249801-2009
  • 财政年份:
    2014
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2020-03893
  • 财政年份:
    2022
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2020-03893
  • 财政年份:
    2021
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2019
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2018
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2017
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2016
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Carbohydrates, enzymes and natural products
碳水化合物、酶和天然产物
  • 批准号:
    RGPIN-2015-03876
  • 财政年份:
    2015
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Enzymes involved in the biosynthesis of carbohydrates and plant natural products
参与碳水化合物和植物天然产物生物合成的酶
  • 批准号:
    138133-2008
  • 财政年份:
    2012
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Enzymes involved in the biosynthesis of carbohydrates and plant natural products
参与碳水化合物和植物天然产物生物合成的酶
  • 批准号:
    138133-2008
  • 财政年份:
    2011
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
Enzymes involved in the biosynthesis of carbohydrates and plant natural products
参与碳水化合物和植物天然产物生物合成的酶
  • 批准号:
    138133-2008
  • 财政年份:
    2010
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    $ 2.62万
  • 项目类别:
    Discovery Grants Program - Individual
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