Engineering enzymes for natural product glycodiversification

用于天然产物糖多样化的工程酶

• 批准号: 249801-2009
• 负责人: Jakeman, David
• 金额: $ 4.37万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=547411
• 关键词: Engineering; enzymes; natural; product; glycodiversification

Our bioorganic chemistry program has the broad goals of furthering an understanding of the physiological roles played by carbohydrate-manipulating enzymes and using these catalysts to perform novel chemistry. The proposed research will use: synthetic chemistry to access novel substrates; mutagenesis and kinetic analyses to probe and evolve catalyst function; and NMR spectroscopy to provide structural insight into protein-ligand interactions.

我们的生物有机化学计划具有广泛的目标，进一步了解碳水化合物操纵酶所发挥的生理作用，并使用这些催化剂来执行新的化学。拟议的研究将使用：用途：合成化学，以获得新的底物;诱变和动力学分析，以探测和演变催化剂功能;和NMR光谱，以提供结构洞察蛋白质-配体相互作用。