Carbohydrates, enzymes and natural products

雅克曼发现资助计划将在生物化学方面做出基础性的科学发现。这些发现将对理解酶的机制产生重大影响，酶是自然界的主要催化剂。它的重点是催化自然科学中普遍存在的重要反应的酶。它将提供对抑制特定酶类或产生更大底物专一性的新方法的洞察。其中一些酶负责产生次生代谢物，这些小分子具有与自然界相互作用的前所未有的能力。其中许多是作为药物或技术工具收获和开发的。我们对酶的研究包括范式转换方法，以合理地改变结构，从而赋予天然产品不同的物理化学性质。 该研究项目将为本科生、研究生(硕士和博士)和PDF学员提供良好的培训环境。学员将在多个领域发展技能，包括：碳水化合物合成、酶学、分子遗传学、天然产物分离和结构阐明。学员将体验到一个日常指导、讨论和解决问题至关重要的环境。他们将获得及时的书面和口头研究结果的鼓励和反馈，以确保他们将发挥最大的潜力。不同培训级别的学员之间的合作有助于培养沟通技能和提高解决问题的能力。学员将学习与现实世界相关的研究技能，以便在完成培训后为他们提供最佳机会。 雅克曼是一名职业生涯中期的研究员，在高质量的学术期刊上发表新的研究成果方面有着出色的记录。他在加拿大和世界各地都有广泛的合作者网络，并与之合作出版了作品。他的研究项目的学员作为科学家在加拿大和其他地方的工业界和学术界取得了非常成功的成就。

The Jakeman discovery grant program will make fundamental scientific discoveries in biological chemistry. These discoveries will have a significant impact on understanding the mechanisms of enzymes, Nature’s predominant catalysts. It focuses upon enzymes that catalyze reactions of ubiquitous importance within the natural sciences. It will provide insight into new ways to inhibit specific enzyme classes or to generate greater substrate specificity. Some of these enzymes are responsible for the production of secondary metabolites, small molecules that have unprecedented capacity to interact with the natural world. Many have been harvested and developed as drugs or technological tools. Our studies on the enzymes include paradigm shifting methods to rationally alter the structures, and hence confer different physicochemical properties on natural products. The program of research will provide an excellent training environment for undergraduate, graduate (MSc and PhD) and PDF trainees. Trainees will develop skills in multiple areas including: carbohydrate synthesis, enzymology, molecular genetics, and natural products isolation and structure elucidation. Trainees will experience an environment where daily guidance, discussion and problem-solving are of paramount importance. They will be provided with timely encouragement and feedback on written and oral research results to ensure that they will achieve their maximum potential. Collaboration between trainees at different levels of training helps develop communication skills and improve problem-solving. The trainees will learn research skills relevant to the real-world to provide them with optimum opportunities upon completion of training. Jakeman is a mid-career researcher with an excellent track record of publishing novel research findings in high quality academic journals. He has an extensive network of collaborators within Canada and worldwide with whom he has published. Trainees from his research program have been highly successful as scientists, in industry and academia within Canada and elsewhere.