Wireless neurophotonic probes for the interrogation of neurons in memory circuits

用于询问记忆电路中神经元的无线神经光子探针

• 批准号: 508406-2017
• 负责人: Poon, Joyce
• 金额: $ 8.41万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=621903
• 关键词: Wireless; neurophotonic; probes; interrogation; neurons

As the average age of the population of Canada and the developed world rises,neurodegenerative conditions will become increasingly prevalent and a growing burden onthe healthcare system and economy. A major neurodegenerative disease is Alzheimersdisease (AD), which causes memory and cognition loss. AD and dementia affect roughly 1.1million Canadians and incur an economic cost of $10.4B per year in Canada. Currently, thereis no cure or effective treatment. The Lancet Neurology Commission recently stated, aneffective therapy for AD is perhaps the greatest unmet need facing modern medicine."This project addresses the challenge of understanding neuron circuits in the brain involved inmemory, with the goal of improving the efficacy of neurostimulation therapies for AD anddementia. Such treatments would stimulate specific brain circuits to promote memoryencoding and/or retrieval in patients with AD or dementia. The project will create a new typeof wireless, implantable deep brain probes for rodent experiments on memory loss rescuethat uses optical stimulation and electrical stimulation+recording of specific groups ofneurons. Importantly, these brain probes will be made using the same processes andinfrastructure as semiconductor microelectronics to ensure compatibility with volumemanufacturing and a viable technology translation path that will widely benefit neuroscientistsand clinical researchers.This project brings together world-class expertise from around the globe in photonics,electronics, neuroscience, and deep brain stimulation. In addition to the Canadian teammembers, the project involves collaborators in France and United States who will providecomplementary expertise in the design, fabrication, and testing of the neural probes. Theresults of this international project will benefit the health of Canadians and lead to high-valueneurotechnology products that are designed and integrated in Canada.

随着加拿大和发达国家人口平均年龄的上升，神经退行性疾病将变得越来越普遍，并对医疗保健系统和经济造成越来越大的负担。一种主要的神经退行性疾病是阿尔茨海默病（AD），其导致记忆和认知丧失。AD和痴呆症影响大约110万加拿大人，每年在加拿大造成104亿美元的经济损失。目前，没有治愈或有效的治疗方法。柳叶刀神经病学委员会最近指出，AD的有效治疗可能是现代医学面临的最大未满足的需求。“这个项目解决了理解大脑中涉及记忆的神经元回路的挑战，目的是提高神经刺激疗法对AD和痴呆症的疗效。这种治疗将刺激特定的大脑回路，以促进AD或痴呆患者的记忆编码和/或检索。该项目将创建一种新型的无线植入式脑深部探针，用于啮齿动物记忆丧失救援实验，该实验使用光刺激和电刺激+记录特定的神经元组。重要的是，这些大脑探针将使用与半导体微电子相同的工艺和基础设施来制造，以确保与批量制造的兼容性和可行的技术转化路径，这将使神经科学家和临床研究人员广泛受益。该项目汇集了来自地球仪的光子学，电子学，神经科学和深部脑刺激领域的世界级专业知识。除了加拿大团队成员外，该项目还涉及法国和美国的合作者，他们将在神经探针的设计，制造和测试方面提供补充专业知识。该国际项目的成果将有益于加拿大人的健康，并导致在加拿大设计和集成的高价值的欧洲技术产品。