Wireless neurophotonic probes for the interrogation of neurons in memory circuits

用于询问记忆电路中神经元的无线神经光子探针

• 批准号: 508406-2017
• 负责人: Poon, Joyce
• 金额: $ 17.05万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Collaborative Health Research Projects
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=662448
• 关键词: Wireless; neurophotonic; probes; interrogation; neurons

As the average age of the population of Canada and the developed world rises,**neurodegenerative conditions will become increasingly prevalent and a growing burden on**the healthcare system and economy. A major neurodegenerative disease is Alzheimers**disease (AD), which causes memory and cognition loss. AD and dementia affect roughly 1.1**million Canadians and incur an economic cost of $10.4B per year in Canada. Currently, there**is no cure or effective treatment. The Lancet Neurology Commission recently stated, an**effective therapy for AD is perhaps the greatest unmet need facing modern medicine."**This project addresses the challenge of understanding neuron circuits in the brain involved in**memory, with the goal of improving the efficacy of neurostimulation therapies for AD and**dementia. Such treatments would stimulate specific brain circuits to promote memory**encoding and/or retrieval in patients with AD or dementia. The project will create a new type**of wireless, implantable deep brain probes for rodent experiments on memory loss rescue**that uses optical stimulation and electrical stimulation+recording of specific groups of**neurons. Importantly, these brain probes will be made using the same processes and**infrastructure as semiconductor microelectronics to ensure compatibility with volume**manufacturing and a viable technology translation path that will widely benefit neuroscientists**and clinical researchers.**This project brings together world-class expertise from around the globe in photonics,**electronics, neuroscience, and deep brain stimulation. In addition to the Canadian team**members, the project involves collaborators in France and United States who will provide**complementary expertise in the design, fabrication, and testing of the neural probes. The**results of this international project will benefit the health of Canadians and lead to high-value**neurotechnology products that are designed and integrated in Canada.

随着加拿大和发达国家人口平均年龄的上升，神经退行性疾病将变得越来越普遍，并对医疗保健系统和经济造成越来越大的负担。一种主要的神经退行性疾病是阿尔茨海默病（AD），其导致记忆和认知丧失。AD和痴呆症影响大约110万加拿大人，每年在加拿大造成104亿美元的经济损失。目前，** 没有治愈或有效的治疗方法。柳叶刀神经病学委员会最近指出，一种有效的治疗AD的方法可能是现代医学面临的最大的未满足的需求。“** 这个项目解决了理解大脑中涉及 ** 记忆的神经元回路的挑战，目的是提高神经刺激疗法对AD和 ** 痴呆症的疗效。这种治疗将刺激特定的大脑回路，以促进AD或痴呆患者的记忆 ** 编码和/或检索。该项目将创建一种新型的无线植入式脑深部探针，用于啮齿动物记忆丧失救援实验，使用光刺激和电刺激+记录特定的神经元组。重要的是，这些大脑探针将使用与半导体微电子相同的工艺和基础设施来制造，以确保与批量生产的兼容性，以及一条可行的技术转化路径，这将使神经科学家和临床研究人员受益。该项目汇集了来自地球仪在光子学、电子学、神经科学和深部脑刺激方面的世界级专业知识。除了加拿大团队成员外，该项目还涉及法国和美国的合作者，他们将在神经探针的设计，制造和测试方面提供补充专业知识。这个国际项目的 ** 成果将有利于加拿大人的健康，并导致在加拿大设计和集成的高价值 ** 神经技术产品。