Mitochondrial translation systems that break the rules

打破规则的线粒体翻译系统

• 批准号: RGPIN-2017-05411
• 负责人: Lang, BFranz
• 金额: $ 4.37万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=628952
• 关键词: Mitochondrial; translation; systems; break; rules

Eukaryotes (i.e. organisms such as animals, plants, and fungi whose cells carry a nucleus) evolved from a mixture of various life forms. Best known is the mitochondrion, the powerhouse of the eukaryotic cell, which goes back to a bacterial symbiont that was acquired by the ancestor of eukaryotes about one billion years ago. This organelle still possesses its own small genome and its own machineries for basic molecular processes including protein synthesis. However, in most eukaryotes, the bacterial ancestry of mitochondria is barely perceptible, since this organelle is exceptionally fast-evolving, often resulting in dramatic changes of basic molecular processes. This has earned mitochondria the reputation as ‘

真核生物（如动物、植物和真菌，其细胞带有细胞核）是由各种生命形式的混合物进化而来的。最著名的是真核细胞的发电站，它可以追溯到大约10亿年前真核生物祖先获得的细菌共生体。这个细胞器仍然拥有自己的小基因组和自己的基本分子过程（包括蛋白质合成）机制。然而，在大多数真核生物中，线粒体的细菌祖先几乎不可察觉，因为这种细胞器非常快速地进化，经常导致基本分子过程的戏剧性变化。这为线粒体赢得了“