Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes

原位分析串联反应进展作为发现和优化合成工艺的手段

• 批准号: RGPIN-2016-04613
• 负责人: Hein, Jason
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632823
• 关键词: Tandem; Reaction; Progress; Situ; Analysis

Chemistry is, first and foremost, an observational science dedicated to explaining change with time. This research proposal applies technology and techniques developed in my group, which utilize data from real-time, in-situ monitoring to allow reactions and process to be visualized rapidly and accurately. These tools are employed in two main research areas. The first centers on the study of homogeneous catalysis, with the aim of understanding reaction mechanisms, discovering new transformations and designing more efficient chemical processes. This application both helps to discover new catalytic transformation and to optimize and refine existing protocols. The second topic focuses on studying and applying selective crystallization using a new continuous crystallization technique, allowing access to bulk quantities of enantiopure compounds. Both projects rely on the ability to quickly and easily delineate complex reaction systems using in situ analysis. Successfully achieving these research goals will dramatically change the chemical research communities approach to new reaction design, as well as delivery technology to revolutionize how enantiopure commodity chemicals are manufactured.

首先，化学是一种观察科学，致力于随着时间的流逝来解释变化。该研究建议应用了我小组中开发的技术和技术，该技术利用实时，原位监视的数据，允许对反应和过程进行快速，准确的可视化。这些工具用于两个主要研究领域。第一批均质催化研究的中心是了解反应机制，发现新的转化并设计了更有效的化学过程。该应用程序都有助于发现新的催化转化，并优化和完善现有协议。第二个主题着重于使用新的连续结晶技术研究和应用选择性结晶，从而可以访问大量的对映基化合物。这两个项目都依赖于使用原位分析快速，轻松地描绘复杂反应系统的能力。成功实现这些研究目标将极大地改变化学研究社区的新反应设计方法，以及交付技术，以彻底改变对映射商品化学品的制造方式。