Tandem Reaction Progress In Situ Analysis as a Means to Discover and Optimize Synthetic Processes

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Chemistry is, first and foremost, an observational science dedicated to explaining change with time. This research proposal applies technology and techniques developed in my group, which utilize data from real-time, in-situ monitoring to allow reactions and process to be visualized rapidly and accurately. These tools are employed in two main research areas. The first centers on the study of homogeneous catalysis, with the aim of understanding reaction mechanisms, discovering new transformations and designing more efficient chemical processes. This application both helps to discover new catalytic transformation and to optimize and refine existing protocols. The second topic focuses on studying and applying selective crystallization using a new continuous crystallization technique, allowing access to bulk quantities of enantiopure compounds. Both projects rely on the ability to quickly and easily delineate complex reaction systems using in situ analysis. Successfully achieving these research goals will dramatically change the chemical research communities approach to new reaction design, as well as delivery technology to revolutionize how enantiopure commodity chemicals are manufactured.