Tandem Reaction Progress Monitoring using the NMReady Flow-Cell System

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The ability to visualize a chemical reaction in real-time is a very powerful and much needed tool. This kind of real-time feedback allows chemical researchers to identify new transformations and study new catalysts. At the same time, this technology is valuable to production and manufacturing, as it allows processes to be optimized more efficiently. Many analytical techniques have been adapted to probe chemical reactions in real-time, however, most have serious restrictions on the kind of reaction that can be investigated, or require significant effort to prepare samples for visualization. This is especially true for analysis by Nuclear Magnetic Resonance (NMR). Despite the wealth of kinetic and structural information available through this technique, broad application has been hampered by the technical challenges of sampling and analysis. The challenge is to design and integrate an efficient workflow that allows any reaction to be probed quickly, accurately and with minimal perturbation of the system under study. This project will develop new technology through a partnership with Nanalysis and researchers at the University of British Columbia. This team has separately developed new NMR hardware (Nanalysys) and automated robotic sampling (UBC) that, when combined, will provide a new broadly applicable NMR analysis technique.