Tandem Reaction Progress Monitoring using the NMReady Flow-Cell System

使用 NMReady 流动池系统监测串联反应进度

• 批准号: 490994-2015
• 负责人: Hein, Jason
• 金额: $ 1.82万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=586705
• 关键词: Tandem; Reaction; Progress; Monitoring; using

The ability to visualize a chemical reaction in real-time is a very powerful and much needed tool. This kind of real-time feedback allows chemical researchers to identify new transformations and study new catalysts. At the same time, this technology is valuable to production and manufacturing, as it allows processes to be optimized more efficiently. Many analytical techniques have been adapted to probe chemical reactions in real-time, however, most have serious restrictions on the kind of reaction that can be investigated, or require significant effort to prepare samples for visualization. This is especially true for analysis by Nuclear Magnetic Resonance (NMR). Despite the wealth of kinetic and structural information available through this technique, broad application has been hampered by the technical challenges of sampling and analysis. The challenge is to design and integrate an efficient workflow that allows any reaction to be probed quickly, accurately and with minimal perturbation of the system under study. This project will develop new technology through a partnership with Nanalysis and researchers at the University of British Columbia. This team has separately developed new NMR hardware (Nanalysys) and automated robotic sampling (UBC) that, when combined, will provide a new broadly applicable NMR analysis technique.

实时可视化化学反应的能力是一个非常强大和迫切需要的工具。这样一种 实时反馈使化学研究人员能够识别新的转化并研究新的催化剂。在 同时，这项技术对生产和制造很有价值，因为它允许优化工艺 效率更高。许多分析技术已经被采用来实时探测化学反应， 然而，大多数人对可以调查的反应类型有严格的限制，或者需要显著的反应 努力准备用于可视化的样本。对于核磁共振分析来说，情况尤其如此 (核磁共振)。尽管通过这种技术可以获得丰富的动力学和结构信息，但广泛的 由于采样和分析的技术挑战，应用一直受到阻碍。挑战在于设计 并集成一个高效的工作流，允许快速、准确、最少地探测任何反应 正在研究的系统的摄动。该项目将通过与以下公司合作开发新技术 不列颠哥伦比亚省大学的Nanalysis和研究人员。这个团队已经单独开发了新的核磁共振 硬件(Nanalysys)和自动机器人采样(UBC)相结合，将提供新的广泛的 适用的核磁共振分析技术。