Combined HPLC-NMR reaction progress monitoring using the NMReady.

实时可视化化学反应的能力是一个非常强大和急需的工具。使用这种方法的实时反馈将使化学研究人员能够识别新的转化和研究新的催化剂。同时，该技术还需要安全地控制生产和制造过程。许多分析技术已被用于实时探测化学反应，然而，大多数分析技术对可以研究的反应类型有严格的限制，或者需要大量的工作来保存样品以进行可视化。这对于核磁共振（NMR）分析尤其如此。尽管通过这种技术可以获得丰富的动力学和结构信息，但由于取样和分析的技术挑战，广泛的应用受到阻碍。挑战在于设计和整合一个高效的工作流程，使任何反应都能快速、准确地探测，并且对所研究的系统的干扰最小。该项目将通过与Nanalysis和不列颠哥伦比亚省大学的研究人员合作开发新技术。该团队分别开发了新的NMR硬件（Nanalysys）和自动机器人采样（UBC），当它们结合在一起时，将提供一种新的广泛适用的NMR分析技术。

The ability to visualize a chemical reaction in real-time is a very powerful and much needed tool. Real-timefeedback using this approach would allow chemical researchers to identify new transformations and study newcatalysts. At the same time, this technology is needed to safely control production and manufacturingprocesses. Many analytical techniques have been adapted to probe chemical reactions in real-time, however,most have serious restrictions on the kind of reaction that can be investigated, or require significant effort toprepare samples for visualization. This is especially true for analysis by Nuclear Magnetic Resonance (NMR).Despite the wealth of kinetic and structural information available through this technique, broad application hasbeen hampered by the technical challenges of sampling and analysis. The challenge is to design and integratean efficient workflow that allows any reaction to be probed quickly, accurately and with minimal perturbationof the system under study. This project will develop new technology through a partnership with Nanalysis andresearchers at the University of British Columbia. This team has separately developed new NMR hardware(Nanalysys) and automated robotic sampling (UBC) that, when combined, will provide a new broadlyapplicable NMR analysis technique.