Combined HPLC-NMR reaction progress monitoring using the NMReady.

实时可视化化学反应的能力是一个非常强大和迫切需要的工具。使用这种方法的实时反馈将使化学研究人员能够识别新的转化和研究新的催化剂。同时，这项技术也是安全控制生产和制造过程所必需的。许多分析技术已经被采用来实时探测化学反应，然而，大多数对可以研究的反应的种类有严重的限制，或者需要大量的工作来制备样品以进行可视化。核磁共振分析尤其如此。尽管这项技术提供了丰富的动力学和结构信息，但采样和分析的技术挑战阻碍了广泛的应用。挑战是设计和集成一个高效的工作流程，允许快速、准确地探测任何反应，并对正在研究的系统进行最小程度的扰动。该项目将通过与不列颠哥伦比亚大学的Nanalysis和研究人员合作开发新技术。该团队分别开发了新的核磁共振硬件(Nanalysys)和自动机器人采样(UBC)，两者结合在一起将提供一种新的广泛适用的核磁共振分析技术。

The ability to visualize a chemical reaction in real-time is a very powerful and much needed tool. Real-timefeedback using this approach would allow chemical researchers to identify new transformations and study newcatalysts. At the same time, this technology is needed to safely control production and manufacturingprocesses. Many analytical techniques have been adapted to probe chemical reactions in real-time, however,most have serious restrictions on the kind of reaction that can be investigated, or require significant effort toprepare samples for visualization. This is especially true for analysis by Nuclear Magnetic Resonance (NMR).Despite the wealth of kinetic and structural information available through this technique, broad application hasbeen hampered by the technical challenges of sampling and analysis. The challenge is to design and integratean efficient workflow that allows any reaction to be probed quickly, accurately and with minimal perturbationof the system under study. This project will develop new technology through a partnership with Nanalysis andresearchers at the University of British Columbia. This team has separately developed new NMR hardware(Nanalysys) and automated robotic sampling (UBC) that, when combined, will provide a new broadlyapplicable NMR analysis technique.