Radicals at Interfaces: Understanding and Exploiting the Physical Behaviour of Radicals on the Surfaces of Biological and Bulk Materials

界面处的自由基：了解和利用生物和散装材料表面上自由基的物理行为

• 批准号: RGPIN-2015-05488
• 负责人: DiLabio, Gino
• 金额: $ 2.55万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=649293
• 关键词: Radicals; Interfaces; Understanding; Exploiting; Physical

Chemical species known as radicals tend to be highly reactive because they have one or more unpaired electrons.  In living systems, oxygen-centred radicals are present because of the respiration of oxygen.  These oxygen-centred radicals are extremely damaging to biological materials such as proteins because they initiate chemical reactions that destroy biomaterial function and consequently induce disease states.  In high-technology applications, radicals often serve as defect centres that inhibit the performance of electronic devices such as computer chips by acting as charge-traps.  In both of these diverse example systems, radicals are ubiquitous.***My research uses computational chemistry and physics tools to simulate systems in which radicals are important.  We also work in close collaboration with experimentalists who test our predictions and help us to implement our ideas.  I am working toward understanding the physical properties of radicals in biological systems in order to prevent their damaging effects and solid-state systems to exploit their unique properties for technological applications.  In the case of biological systems, my research group is studying how radicals chemically damage biological molecules like proteins.  This will allow us to understand how these deleterious reactions are inhibited naturally in biological systems and how chemical intervention can play a role in preventing diseases that may be caused by radicals.  In solid-state systems, we seek to exploit the unique character associated with radicals in order to create new hybrid systems with interesting and viable functionality.  We will do this by simulating semiconducting and conducting surfaces functionalized with nanostructured radical species.  Ultimately, the goal of our work is to provide benefit to Canada by developing insights into how radicals contribute to diseases like Alzheimer's and Parkinson's and into new electronic technologies that have the potential to be put into production. **

被称为自由基的化学物质往往具有高活性，因为它们有一个或多个不成对的电子。在生命系统中，以氧为中心的自由基是由于氧的呼吸作用而存在的。这些以氧为中心的自由基对蛋白质等生物材料极具破坏性，因为它们引发化学反应，破坏生物材料的功能，从而诱发疾病状态。在高科技应用中，自由基通常作为缺陷中心，通过充当电荷陷阱来抑制电子设备（如计算机芯片）的性能。在这两个不同的例子系统中，自由基都是普遍存在的。***我的研究使用计算化学和物理工具来模拟自由基很重要的系统。我们还与实验学家密切合作，他们测试我们的预测并帮助我们实现我们的想法。我正在努力了解自由基在生物系统中的物理性质，以防止它们的破坏性影响，并在固态系统中利用它们的独特性质进行技术应用。就生物系统而言，我的研究小组正在研究自由基如何用化学方法破坏蛋白质等生物分子。这将使我们了解这些有害反应是如何在生物系统中被自然抑制的，以及化学干预如何在预防可能由自由基引起的疾病中发挥作用。在固态系统中，我们寻求利用与自由基相关的独特特征，以创造具有有趣和可行功能的新混合系统。我们将通过模拟纳米结构自由基功能化的半导体和导电表面来做到这一点。最终，我们工作的目标是通过深入了解自由基是如何导致阿尔茨海默氏症和帕金森症等疾病的，以及有可能投入生产的新电子技术，为加拿大带来好处。**