Ultrafast Pulsed Laser Source for the Spectroscopic Integration (SPIN) Program

用于光谱积分 (SPIN) 计划的超快脉冲激光源

• 批准号: RTI-2019-00504
• 负责人: Holzman, Jonathan
• 金额: $ 10.68万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=653797
• 关键词: Ultrafast; Pulsed; Laser; Source; Spectroscopic

***The Spectroscopic Integration (SPIN) Program is a multidisciplinary initiative between researchers at the University of British Columbia's Okanagan campus in collaboration with the British Columbia Cancer Agency. The SPIN Program was established in 2015 to develop spectroscopic technologies for effective detection of cancerous tissue and high-sensitivity monitoring on the response of cancerous tissue to radiation therapy. The impact of such technologies can be significant, in that they would enable early diagnoses (within clinical settings) and personalization of treatments (via adaptations to the prescribed radiation therapy).******The SPIN Program's core spectroscopic technologies are based upon terahertz and Raman spectroscopy. The technologies are being developed for, and ultimately integrated within, lab-on-a-chip devices. Preliminary research has shown great promise for the integration of these core technologies. Raman spectroscopy is an established technology for characterizations of cancerous tissue—albeit with known challenges. Terahertz spectroscopy is an emerging technology that has recently been shown to have heightened sensitivity to the physiological markers of cancerous tissue—although the underlying mechanisms are not yet fully known. The SPIN Program is leveraging the complementary nature of the terahertz and Raman spectroscopic technologies and applying them within lab-on-a-chip devices. The two technologies would have improved potential for the discrimination of cancerous and healthy tissue on a cellular level, while the lab-on-a-chip device architecture would support future clinical implementation.******The SPIN Program has made great strides in its integrative research, although it recently encountered a critical issue relating to the failing of its main research tool, being an ultrafast pulsed laser source. The ultrafast pulsed laser source that is used to generate and detect terahertz radiation has failed—and this has jeopardized much of the work in the program. This NSERC Research Tools and Instruments proposal is a response to this issue in that it requests an ultrafast pulsed laser source (and related support equipment). The acquisition of this research tool is essential to the SPIN Program, in that it would allow the program to continue its research activities, support its personnel, and ultimately realize effective technologies for cancer therapy.**

*光谱集成(SPIN)计划是不列颠哥伦比亚大学奥卡纳根校区的研究人员与不列颠哥伦比亚省癌症研究所合作的一项多学科倡议。SPIN计划成立于2015年，旨在开发有效检测癌症组织和高灵敏度监测癌症组织对放射治疗反应的光谱技术。这些技术的影响可能是巨大的，因为它们将使早期诊断(在临床环境中)和个性化治疗(通过适应处方的放射疗法)成为可能。*SPIN计划的核心光谱技术基于太赫兹和拉曼光谱。这些技术是为芯片实验室设备开发的，并最终集成到其中。初步研究表明，这些核心技术的整合前景广阔。拉曼光谱是一项用于表征癌症组织特征的成熟技术--尽管存在已知的挑战。太赫兹光谱学是一项新兴的技术，最近被证明对癌症组织的生理标记物具有高度的敏感性-尽管潜在的机制尚未完全清楚。SPIN计划利用太赫兹和拉曼光谱技术的互补性，并将其应用于芯片实验室设备中。这两项技术将提高在细胞水平上区分癌症和健康组织的潜力，而芯片实验室设备架构将支持未来的临床应用。SPIN计划在综合研究方面取得了很大进展，尽管它最近遇到了与其主要研究工具失败有关的关键问题，即超快脉冲激光光源。用来产生和探测太赫兹辐射的超快脉冲激光光源发生了故障--这危及了该计划的大部分工作。NSERC的这份研究工具和仪器提案就是对这一问题的回应，因为它需要一个超快脉冲激光源(和相关的支持设备)。收购这一研究工具对SPIN计划至关重要，因为它将使该计划能够继续其研究活动，支持其人员，并最终实现癌症治疗的有效技术。