Organofluorine Chemistry: From New Synthetic Methods to New Reactivity

有机氟化学：从新合成方法到新反应性

• 批准号: RGPIN-2020-04265
• 负责人: Paquin, JeanFrançois
• 金额: $ 6.85万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=716916
• 关键词: Organofluorine; Chemistry; New; Synthetic; Methods

The unique properties of fluorine are key in why this atom and fluorinated groups (CF3, CF2H, etc.) are now key substituents on organic compounds for applications in chemical biology, in medicinal chemistry, in agrochemistry, and in the material sciences. This field needs a deeper fundamental understanding of fluorinated molecule reactivity, and innovative, practical methods for their synthesis. The long-term vision of my research program is to contribute state-of-the-art methods for the synthesis of organofluorine molecules, and to broaden the collective knowledge of the reactivity/behaviour of this unique class of compounds. During the last funding period, we accomplished significant advances that have improved synthetic, medicinal, and bioorganic chemistry. This Discovery Grant renewal will continue this successful program. We intend to concentrate our efforts in the next five years in three major research areas with significant high-impact potential: 1) Exploring new frontiers in the synthesis of pentafluorosulfanylated compounds 2) Exploiting the CF bond as a directing group 3) Improving the synthesis of monofluoroalkenes

氟的独特性质是为什么这个原子和氟化基团（CF 3，CF2 H等）现在是有机化合物的关键取代基，用于化学生物学、药物化学、农业化学和材料科学。 这一领域需要对氟化分子的反应性有更深入的基本了解，并需要创新的、实用的合成方法。我的研究计划的长期愿景是为有机氟分子的合成提供最先进的方法，并扩大这类独特化合物的反应性/行为的集体知识。在上一个资助期间，我们取得了重大进展，改善了合成，医药和生物有机化学。这次发现补助金更新将继续这一成功的计划。我们打算在未来五年内集中精力在三个具有重大影响潜力的主要研究领域： 1)探索五氟硫烷基化合物合成的新前沿 2)利用CF键作为导向基团 3)单氟烯烃合成工艺的改进