Etudes des mécanismes de l'adaptation et des relations interneuronales au cortex.

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* **During the last cycle my lab*investigated two themes. A) The influence of adaptation on changes of*preferred stimulus in visual cortex; our findings point to opportunities to explore plasticity of*neurons and neuronal networks. B) The functional*relationships between neurons forming a connectome. This topic suggests*a process of encoding neuronal signals.***Our research program aims to further develop*the above innovative topics in order to understand fundamental *mechanisms of plasticity and the dynamics of population encoding in the CNS. Our proposed program deals with the two hottest*topics: plasticity and dynamics of connectomes. ***Experiments are carried out on*anesthetized animals. Electrode matrices are lowered into the cortex. The*following specific subjects will be investigated.***A) Influence of an initial stimulus upon responses evoked*by a following stimulus. Stimuli leave a trace.*In the initial phase we apply two types of stimuli. The first conditioning short stimulus is constant, that is,*exhibiting an identical property, the second conditioning*stimulus (same type) projects a variable property e.g.orientations. Conditioning stimuli are*followed at a predetermined interval by a test stimulus. The hypothesis is how each of the*conditioning stimuli affects the responses to the test stimulus?