Etudes des mécanismes de l'adaptation et des relations interneuronales au cortex.

在上一个周期中，我的实验室 研究了两个主题。（一）适应变化的影响 我们的研究结果指出，有机会探索可塑性， 神经元和神经元网络。 B）功能 形成连接体的神经元之间的关系。本专题建议 神经元信号的编码过程。 我们的研究计划旨在进一步发展 上述创新主题，以了解基本的 可塑性机制和CNS中群体编码的动力学。 我们提出的计划涉及两个最热门的 题目：连接体的可塑性和动力学。 实验是在 麻醉动物电极矩阵被降低到皮层中。的 将对以下具体问题进行调查。 A）初始刺激对诱发反应的影响 一个后续的刺激。 刺激会留下痕迹。 在初始阶段，我们应用两种类型的刺激。第一个条件反射短刺激是恒定的，即， 表现出相同的性质，第二调节 刺激（相同类型）投射可变属性，例如取向。条件刺激是 然后以预定的间隔进行测试刺激。假设是每一个 条件刺激会影响对测试刺激的反应？

During the last cycle my lab investigated two themes. A) The influence of adaptation on changes of preferred stimulus in visual cortex; our findings point to opportunities to explore plasticity of neurons and neuronal networks. B) The functional relationships between neurons forming a connectome. This topic suggests a process of encoding neuronal signals. Our research program aims to further develop the above innovative topics in order to understand fundamental mechanisms of plasticity and the dynamics of population encoding in the CNS. Our proposed program deals with the two hottest topics: plasticity and dynamics of connectomes. Experiments are carried out on anesthetized animals. Electrode matrices are lowered into the cortex. The following specific subjects will be investigated. A) Influence of an initial stimulus upon responses evoked by a following stimulus. Stimuli leave a trace. In the initial phase we apply two types of stimuli. The first conditioning short stimulus is constant, that is, exhibiting an identical property, the second conditioning stimulus (same type) projects a variable property e.g.orientations. Conditioning stimuli are followed at a predetermined interval by a test stimulus. The hypothesis is how each of the conditioning stimuli affects the responses to the test stimulus?