Radio Frequency Identification-Assisted Intestinal Biome Sampling Device

Nimble Science Ltd.需要SAIT的协助，为其可消化的小肠微生物组吸入（SIMBA）胶囊原型添加无线跟踪系统作为增值功能。SAIT将通过将射频识别（RFID）技术集成到胶囊中来解决该公司的挑战，该胶囊将与采样垫一起激活，并传输信号以无线方式跟踪通过消化道的采样过程。小肠是宿主、药物、食物和微生物相互作用的地方。所述胶囊是一种两级装置，在外胶囊溶解时开始流体取样；然后在一段固定的时间间隔后，第二阶段停止采样，将样品机械密封，以便以后恢复。了解采样装置的驱动瞬间将改善提取的数据，并实际上消除目前临床试验中需要的六种低剂量x射线。技术挑战是将无源RFID设备与Nimble的专有采样技术集成在一起，以发出从胶囊开始和停止采样的信号。此外，没有商业上可用的RFID设备具有跟踪上述采样过程所需的功能。拟议中的项目将使用生物信息学和通信技术等新兴平台。

Nimble Science Ltd. needs SAIT's assistance to add a wireless tracking system as a value-added feature to its ingestible small intestine microbiome aspiration (SIMBA) capsule prototype. SAIT will address this company challenge by integrating radio frequency identification (RFID) technology to the capsule that will activate along with the sampling pad and transmit a signal to wirelessly track the progress of the sampling procedure through the digestive tract. The small intestine is where host, drug, food and microbiome interact. The capsule is a two-stage device that begins fluid sampling on dissolution of an outer capsule; then after a fixed interval a second stage occurs where sampling ceases and the specimen is mechanically sealed for later recovery. Knowing the instant of actuation of the sampling device will improve the extracted data and virtually eliminate the six low-dose X-rays presently needed in their clinical trials. The technical challenge is to integrate a passive RFID device with Nimble's proprietary sampling technology to signal the initiation and cessation of sampling from the capsule. In addition, there is no commercially available RFID device with the features required to track the above sampling process. The proposed project will use emerging platforms such as bioinformatics and communication technologies.