Leveraging Signal Deconvolution to Enable Reaction Monitoring using Bench-top Nuclear Magnetic Resonance

利用信号解卷积通过台式核磁共振实现反应监测

• 批准号: 576847-2022
• 负责人: Hein, JasonJEH
• 金额: $ 2.19万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747433
• 关键词: Leveraging; Signal; Deconvolution; Enable; Reaction

The ability to visualize a chemical reaction in real-time is a very powerful process which allows for researchers to make informed decisions which can overall expedite research, enhance process safety, and/or promote reaction efficiency. In the modern laboratory, there are many process analytical tools (PATs) capable of providing such information, each with a unique set of benefits and limitations. Nuclear magnetic resonance (NMR) spectroscopy is a unique tool among them, as it can provide both detailed structural and quantitative insights into the system under study, without the need for external calibration. Despite having these advantages, traditional high-field (HF) NMR instrumentation suffers from large physical footprint and high purchase/maintenance cost, overall limiting its abilities to conveniently be applied in a synthetic laboratory. Low-field (LF) benchtop NMR spectrometers, on the other hand, avoid these physical and monetary limitations, allowing for real-time reaction monitoring to be accessible and routinely accessed in these settings. However, benchtop NMR is not a widely applied tool as the resultant data is harder to interpret and analyze for common nuclei (such as 1H, due to higher propensity for signal overlap and decrease in sensitivity) than data collected with HF instruments. This project will develop and validate new data processing and analysis workflow, utilizing a newly developed software solution, resulting in quantitative reaction monitoring to be more readily achieved with LF benchtop NMR. This will be done through a partnership between Nanalysis Corp. (NAN), and the Hein lab at the University of British Columbia (UBC). The goal of the project is to make benchtop NMR a more reliable PATs for reaction monitoring in both industry and academia settings.

实时可视化化学反应的能力是一个非常强大的过程，它允许研究人员做出明智的决定，这可以全面加快研究，提高过程安全性和/或提高反应效率。在现代实验室中，有许多过程分析工具（PAT）能够提供这些信息，每个都有一套独特的优点和局限性。核磁共振（NMR）光谱是其中一个独特的工具，因为它可以提供详细的结构和定量的见解，在研究中的系统，而不需要外部校准。尽管具有这些优点，但是传统的高场（HF）NMR仪器遭受大的物理占地面积和高的购买/维护成本，总体上限制了其方便地应用于合成实验室的能力。另一方面，低场（LF）台式NMR光谱仪避免了这些物理和金钱上的限制，允许在这些设置中访问和常规访问实时反应监测。然而，台式NMR不是一种广泛应用的工具，因为与HF仪器收集的数据相比，所得数据更难解释和分析常见核（例如1H，由于信号重叠和灵敏度降低的倾向更高）。该项目将开发和验证新的数据处理和分析工作流程，利用新开发的软件解决方案，使定量反应监测更容易实现LF台式NMR。这将通过Nanalysis Corp.（NAN）和不列颠哥伦比亚省大学（UBC）的Hein实验室之间的合作来完成。该项目的目标是使台式NMR成为工业和学术界反应监测的更可靠的PAT。