Autonomic Nervous System Control of the Cardiac Pacemaker: Modeling Aspects

心脏的窦房结是由极其重要的组织组成的，因为它是负责心率的结节。约翰·W·克拉克博士正在研究窦房结的起搏器作用和控制这一功能的自主神经，在这个过程中，他正在利用自己的工程学背景，试图将这一功能转化为数学模型。克拉克博士将在他的模型中融入各种细胞功能，包括细胞内和细胞外。这项工作本身很重要，因为它关注的是生物结构。然而，这项工作是开创性的，因为它试图量化另一个生物系统。这项工作将代表着我们对心脏窦房结细胞的运作和调节的理解有了实质性的进步。

The sino-atrial node of the heart is comprised of extremely important tissue since it is this node which is responsible for the heart rate. Dr. John W. Clark is studying the pacemaker role of the sino-atrial node and the autonomic nerves which control this function and in the process he is using his engineering background to try to put this function into a mathematical model. Dr. Clark will incorporate into his model the various cell functions, both intracellular and extracellular. This work is important in itself because of the biological structure upon which it concentrates. However, this work is ground breaking since it attempts to quantify another biological system. This work will represent a substantial advance in our understanding of the operation and modulation of the sino-atrial node cells of the heart.