New Carbon-Carbon Bond-Forming and -Cleaving Organometallic Reactions

合成有机项目将支持普渡大学化学系根岸英一博士的研究。根岸博士将继续他在过渡金属配合物催化或促进的有机金属碳-碳键形成反应方面的创新研究，特别是涉及锆和铪的反应。这项研究包括发现和发展具有合成吸引力的有机金属新反应，以及探索基本有机金属反应模式的范围和机理。根岸博士的研究将集中在四个领域：(1)有机锆和有机铪化合物的催化反应；(2)有机锆和有机铪化合物的非对映选择性和非对映选择性反应；(3)锆二烯和铪二烯衍生物的化学进一步探索；(4)有机锆和有机铪化合物的结构和机理研究。在这些研究中，根岸博士还将系统地研究迁移插入反应的范围，重点是那些涉及d-嵌段过渡金属的反应。

The Synthetic Organic Program will support the research of Dr. Ei-ichi Negishi of the Department of Chemistry at Purdue University. Dr. Negishi will continue his innovative studies on organometallic carbon-carbon bond forming reactions catalyzed or promoted by transition metal complexes, especially ones involving zirconium and hafnium. This study includes discovery and development of synthetically attractive new organometallic reactions and exploration of the scope and mechanism of funda- mental organometallic reaction patterns. Dr. Negishi will focus his research in four areas: (1) catalytic reactions of organozirconium and organohafnium compounds, (2) diastereoselective and enantioselective reactions of organozirconium and organohafnium compounds, (3) further exploration of the chemistry of zirconicene and hafnicene derivatives, and (4) stuctural and mechanistic studies of organozirconium and organohafnium compounds. In these studies Dr. Negishi will also systematically investigate the scope of migratory insertion reactions with emphasis on those involving d-block transition metals.