Synthetic and Mechanistic Studies on the Homogeneous Catalysis of Transition Metal Complexes

该项目侧重于三项主要工作。首先，将对Co-Rh混合金属催化剂体系进行机理研究，探讨Co-Rh双金属二核和四核配合物对1-炔的高度区域选择性和立体选择性的硅甲酰化和硅氢化的催化作用。其次，将硅甲酰化反应应用于烷基胺的硅甲酰化环化反应和硅甲酰化碳环化反应，作为获得功能化杂环的途径。第三，将通过在羰基化中使用螯合定向区域和立体控制来研究有效不对称诱导的方法。有了这个奖项，合成有机项目再次支持纽约州立大学石溪分校化学系Iwao Ojima博士的研究。这项工作的最终目标是设计和开发多功能多催化剂系统，使化学家能够在一个反应容器中以高度有组织的方式进行多步合成。该研究将提供新的高效的合成方法，并提高对双金属催化和过渡金属配合物介导的区域和立体控制的认识。

The project focuses on three major efforts. First, a mechanistic study on Co-Rh mixed metal catalyst systems will be carried out to probe catalysis by Co-Rh bimetallic di- and tetranuclear complexes with regard to the highly regio- and stereoselective silylformylation and hydrosilylation of 1-alkynes. Second, applications of the silylformylation reaction to the silylformylation-annulation of alkynyl amines and silylformylation-carbocyclization will be examined as a route to functionalized heterocycles. Third, approaches to effective asymmetric induction will be studied by the use of chelation-directed regio- and stereocontrol in carbonylations. %%% With this award the Synthetic Organic Program renews support of the research of Dr. Iwao Ojima of the Department of Chemistry at the State University of New York, Stonybrook. The ultimate goal of the work is to design and develop multi-functional multi-catalyst systems that will enable the chemist to carry out multi-step synthesis in one reaction vessel in a highly organized manner. The research wiil provide new and efficient synthetic methods, and an improved understanding of both bimetallic catalysis and regio- and stereocontrol mediated by transition metal complexes.