Upgrade and Acquisition of NMR Instrumentation

这项来自学术研究基础设施计划的奖项将帮助亚利桑那大学化学系获得一台500 MHz光谱仪，该光谱仪将用于以下研究调查：1.卟啉类化合物的合成及溶液结构金属卟啉和血红素蛋白；抗磁性和顺磁性卟啉的CP/MAS核磁共振；模型血红素和血红素蛋白的57Fe核磁共振。2.视觉蛋白的多核核磁共振结构研究3.肽类激素和神经递质的核磁共振研究。4.聚合物设计与分子拓扑。5.加氢脱氮催化剂的核磁共振研究6.多肽固体核磁共振谱中~(13)C化学位移的构象依赖性。7.钼酶模型的固体~(95)Mo核磁共振研究8.超分子组装及其组分的核磁共振研究9.糖苷类化合物的新方法学：神经鞘糖脂和O-连接糖肽。10.天然产物、新型聚合物和嵌段共聚物的核磁共振结构测定11.用N-乙酰氨基葡萄糖基核糖核酸探测溶菌酶结合裂隙的E和F亚位。12.有机聚合物化学。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物和催化等领域以及生物学中都是有用的。

This award from the Academic Research Infrastructure Program will help the Department of Chemistry at the University of Arizona acquire a 500 MHz spectrometer which will be used in the following research investigations: 1. Synthesis and Solution Structure of Porphyrins, Metalloporphyrins, and Heme Proteins; CP/MAS NMR of Diamagnetic and Paramagnetic Porphyrins; and 57Fe NMR of Model Hemes and Heme Proteins. 2. Multinuclear NMR Structural Studies of Visual Proteins. 3. NMR Studies of Peptide Hormones and Neurotransmitters. 4. Polymer Design and Molecular Topology. 5. NMR Investigations of Hydrodenitrogenation (HDN) Catalysts. 6. Conformational Dependence of 13C Chemical Shifts in the Solid-State NMR Spectra of Peptides. 7. Solid-State 95Mo NMR Studies of Molybdoenzyme Models. 8. NMR Studies of Supramolecular Assemblies and Their Components. 9. New Methodolgy for Glycosides: Glycosphingolipids and O-Linked Glycopeptides. 10. NMR Structure Determinations of Natural Products and New Polycerams and Block Copolymers. 11. Probing the E and F Subsites of the Lysozyme Binding Cleft With N-Acetylglucosaminyl Muramic Acid. 12. Organic Polymer Chemistry. %%% Nuclear Magnetic Resonance (NMR) Spectroscopy is the most powerful tool available to the chemist for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in areas such as polymers and catalysis, and in biology.