High Voltage Electrophoresis in Capillary Tubes

这个项目是在分析和表面化学的一般领域和分离科学的子领域。在为期40个月的持续资助期间，Jorgenson教授和他的学生将在三个领域开展毛细管区带电泳（CZE）的具体研究。首先，二维分离方案涉及混合液相色谱- cze技术将探讨；其次，将开发新的柱后反应/荧光检测方案，以扩大基于cz的分析技术的多功能性；第三，开发和完善电渗透平衡电泳（ECE）的高分辨率电泳新方法。该项目建立在Jorgenson教授及其学生在美国国家科学基金（NSF）资助CHE-8912926下进行的研究基础上。该项目目标的成功实现将提供强有力的分析工具，适用于广泛的化学、环境和生物问题。%%%

This project is in the general area of analytical and surface chemistry and in the subfield of separation science. During the tenure of this forty-month continuing grant, Professor Jorgenson and his students will carry out research in capillary zone electrophoresis (CZE) with specific thrusts in three areas. First, two-dimensional separations protocols involving hybrid liquid chromatography - cze techniques will be explored; second, new post-column reaction/fluorescence detection protocols will be developed to expand the versatility of cze-based analytical techniques; and third, a new approach to high resolution cze which utilizes electroosmotically counterbalanced electrophoresis (ECE) will be developed and refined. This project builds upon research carried out by Professor Jorgenson and his students under NSF grant CHE-8912926. %%% The successful attainment of the goals of this project will provide strongly enabling analytical tools that will be applicable to a broad spectrum of chemical, environmental, and biological problems.