Integration of Fourier Transform Nuclear Magnetic Resonance Spectroscopy into the Undergraduate Chemistry Curriculum

化学系正在购买一台具有13C和1H共振能力的高场FT-NMR光谱仪，用于改进本科化学课程。我们特别努力将在正式课程中学到的理论与本科生研究计划相结合。13C和1H FT-NMR光谱法的基本原理和实践是在大二的有机化学实验课程中首次介绍的，学生将亲自使用新仪器来测定有机结构。大三到大四的实验课程（物理化学、分析生物化学和仪器分析）集中在傅立叶变换方法的技术方面，以及13C核磁共振和1H核磁共振光谱技术在化学系统定量测量中的应用。具体的核磁共振实验包括平衡常数、热力学性质、pka值和取代基常数的测定；以及酶动力学、立体反应、氢交换速率和反应机理的研究。13C/1H FT-NMR谱仪的使用也提高了学生自主研究的质量和数量，这是课程的重要组成部分。

This Department of Chemistry is purchasing a high field FT-NMR spectrometer with 13C and 1H resonance capabilities for use in the improvement of the undergraduate chemistry curriculum. A particular effort is made to integrate the theory learned in formal courses with the undergraduate student research program. The basic principles and practice of 13C and 1H FT-NMR spectrometry are first introduced in the sophomore Organic Chemistry Laboratory courses where students personally use the new instrument to determine organic structures. The junior- senior laboratory courses (Physical Chemistry, Analytical Biochemistry, and Instrumental Analysis) center on the technical aspects of fourier transform methods and the applications of 13C NMR alongside 1H NMR spectroscopic techniques for quantitative measurements of chemical systems. Specific NMR experiments include the determination of equilibrium constants, thermodynamic properties, pka values, and substituent constants; and studies on enzyme kinetics, stereospecific reactions, hydrogen exchange rates, and reaction mechanisms. The use of the 13C/1H FT-NMR spectrometer also enhances the quality and quantity of student independent research which is an important component of the curriculum.