Purchase of an NMR Spectrometer

9312082埃斯彭森化学研究仪器项目的这一奖项将帮助爱荷华州立大学化学系购买高分辨率400兆赫兹多核核磁共振(核磁共振)光谱仪。这一升级将极大地加强以下领域的研究：1)过渡金属的有机金属化学，2)利用桥头自由基和碳离子开发合成生物碱的新路线，3)利用光化学氢原子提取/环加成探索胸苷和鬼臼毒素的新合成路线，4)金属卟啉的配位和有机金属化学，5)新型杂环化合物的结构和构象表征，6)合成受体与底物的非共价结合，7)有机化合物的基本热反应的研究，8)自由基和电子转移过程的核磁共振研究。核磁共振(核磁共振)光谱仪用于获得有关分子结构(存在什么类型的碳和/或氢原子和/或杂原子，每种类型的原子的相对数量以及它们在分子中如何相互连接)和分子动力学(分子的各个部分移动的速度有多快)的信息。该仪器对于任何有意义的现代合成化学研究项目都是必不可少的。***

9312082 Espenson This award from the Chemistry Research Instrumentation Program will assist the Department of Chemistry at Iowa State University in the purchase of a high resolution 400 MHz, multinuclear, nuclear magnetic resonance (NMR) spectrometer. This upgrade will enhance greatly research in a number of areas including the following: 1) Organometallic chemistry of the transition metals, 2) The development of new synthetic routes to alkaloids using bridgehead radicals and carbanions, 3) The exploration of novel synthetic routes to pleurotin and podophyllotoxin using photochemical hydrogen atom abstraction/cycloaddition, 4) The coordination and organometallic chemistry of metalloporphyrins, 5) Structural and conformational characterization of novel atranes, 6) Non-covalent binding of substrates by synthetic receptors, 7) A study of the fundamental thermal reactions of organic compounds, 8) An NMR study of free radical and electron transfer processes. %%% A nuclear magnetic resonance (NMR) spectrometer is used to obtain information about molecular structure (what types of carbon and/or hydrogen atoms and/or hetero-atoms are present, what are the relative number of each type of atoms and how are they connected to one another in the molecule) and molecular dynamics (how rapidly are the various parts of the molecule moving). This instrument is essential for any meaningful, modern synthetic chemistry research program. ***