Biofunctional Gels for Tissue Engineering in the Peripheral Nerve

9409455 Hubbell这是一项关于开发用于周围神经组织工程的生物材料的研究。这些生物材料由含有合成基质附着肽的纤维蛋白凝胶组成，提供神经传导和神经诱导刺激，以增强神经再生。本研究有三个具体目的：(1)表征纳入纤维蛋白的肽固定化的稳定性；(2)测定掺入肽的生物活性；(3)观察多肽掺入对体内周围神经生成的影响。这项研究可能对人类神经系统疾病的治疗产生影响。＊＊＊

9409455 Hubbell This proposal is on research to develop biomaterials for tissue engineering of the peripheral nerve. These biomaterials are comprised of fibrin gels containing synthetic matrix attachment peptides to provide both neuro-conductive and neuro-inductive stimuli in order to enhance nerve regeneration. This research has three specific aims which are: (1) to characterize the stability of the immobilization of the peptides incorporated into fibrin; (2) to determine the bioactivity of the incorporated peptides; and (3) to examine the effect of peptide incorporation on in vivo peripheral nerve generation. This research could have impact on the treatment of human neurological disease. ***