Gordon Conference on Fibronectin, Integrins, and Related Macromolecules, to be held February 1995 at Oxnard, California

“纤维连接蛋白、整合蛋白和相关大分子”的戈登研究会议将于1995年2月在加州奥克斯纳德举行。作为细胞外粘附素的范例，纤维连接蛋白与跨膜受体的相互作用已被证明适用于许多细胞粘附系统。许多其他细胞外糖蛋白已被描述为具有与纤维连接蛋白相似的生物学特性，其中大多数已被测序，其中一些具有已知的三维结构。这些分子参与后生动物的多种基本细胞功能，在胚胎发生、组织组织、止血、伤口愈合、免疫功能和病理状态等研究领域具有重要意义。在高等植物中也发现了这类蛋白质，但它们在植物中的功能尚不清楚。未来几年，该领域面临的挑战是理解和组织大量新的结构信息，并在此基础上设计实验，了解动物组织中几个看似冗余的粘附系统的相对生物学重要性，并将新的见解应用于实际目的。1995年戈登研究会议将作为一个宝贵的论坛，提出和讨论新的信息，确定问题领域，并规划新的方法。这笔赠款部分支持那些旅费有限而不能参加会议的与会者以及研究涉及植物的申请人的费用。＊＊＊

9413029 Storm The Gordon Research Conference on "Fibronectin, Integrins, and Related Macromolecules" will be held in February, 1995 in Oxnard, California. As the paradigm of an extracellular adhesin, fibronectin interactions with a transmembrane receptor have proven applicable to a number of cellular adhesion systems. Many other extracellular glycoproteins have been described with biological properties similar to fibronectin, most of which have been sequenced and some of which have known three dimensional structures. These molecules are involved in a wide variety of basic cellular functions in metazoans, of significance to such areas of study as embryogenesis, tissue organization, hemostasis, wound healing, immune functions, and pathological states. Proteins of this type have also been discovered in higher plants, and their functions in plants remains to be understood. The challenges to the field over the next several years are to comprehend and organize the large amount of new structural information and design experiments based on it, learn the relative biological importance of the several seemingly redundant adhesion systems in animal tissues, and apply the new insights to practical ends. The 1995 Gordon Research Conference will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches. This grant provides partial support for expenses of conferees with limited travel funds who would otherwise not be able to attend, as well as applicants whose research involves plants. ***