Industry/University Cooperative Research Center for Biosurfaces

拜尔生物表面工业/大学合作研究中心正在成为一个多站点的大学中心。位于布法罗的纽约州立大学工业/大学生物表面合作研究中心正在与孟菲斯大学的一个研究机构和纽约州立陶瓷学院的另一个研究机构合作。多站点中心的研究将涉及：1)在不同有机/无机含量的水介质中，有利于或抑制生物粘附的各种基质的化学/物理性质的表征；2)确定细胞与表征良好的基质相互作用时的表面特性，特别关注介质流动的动力学、细胞到达、表面修饰、生物附着以及最终附着机制的稳定性；3)记录细胞与支撑膜之间的反应，细胞与相邻细胞之间的反应，膜与周围介质之间的反应，以及其他交叉反应，特别关注在实际生物医学或生物工程情况下可能控制这些相互作用以促进或防止生物粘附的技术；4)将这些生物技术扩大到宏观系统过程，如粘合剂分泌或生物矿化，这些过程可能产生新的或模仿现有的材料，如结构复合壳和天然生物体的粘合剂。这个多站点中心由环境系统项目主任诺曼·卡普兰博士协调。纽约州立大学申请资助本科生研究助理。这些学生将参与中心正在进行的研究项目。额外的资金通过补充研究机会奖（ROA）提供给D'Youville学院的一位女性助理教授，为新布法罗州立大学进行研究。该项目正在确定与生物粘合剂功能相关的蛋白质结构。该项目的目标是研究与选定的天然粘附蛋白结构域的结合能力有关的蛋白质结构，并研究它们在开发人造蛋白质粘合剂中的用途。项目经理建议纽约州立大学布法罗分校获得奖励：5年持续奖励的第一年为50,000美元（包括25,000美元的行政活动）；通过分包合同向孟菲斯大学提供为期五年的持续奖励，第一年为5万美元；通过分包合同向纽约州立陶瓷学院（New York State College of Ceramics）提供为期五年的持续奖励，第一年为5万美元；每年5000美元，由妇女、少数民族和残疾人工程研究助理项目提供资金；以及为期24个月的54,995美元的研究机会奖。在每个12个月周期结束时，项目经理和/或工程教育中心部门的部门主管将审查中心在一系列更新标准要求方面的进展情况，包括以下内容：1)行业/大学互动发展的程度；2)支撑基础的发展程度；3)一个强有力的研究项目正在发展的程度。如果评审令人满意，项目经理将建议支持下一阶段的持续奖励。第2页/ 2

9416826 Baier The Industry/University Cooperative Research Center for Biosurfaces is becoming a multi-site university Center. The State University of New York at Buffalo's Industry/University Cooperative Research Center for Biosurfaces is being joined by a research site at the University of Memphis and another research site at the New York State College of Ceramics. Research in the multi-site Center will address: 1) Characterization of the chemical/physical properties of various substrata that favor or inhibit bioadhesion, in aqueous media of varied organic/inorganic content; 2) Determination of the surface properties of cells as they engage in interactions with well- characterized substrata, giving special attention to the dynamics of media flow, cell arrival, surface modification, bio-attachment and -- finally -- stability of the attachment mechanisms; 3) Documentation of reactions between cells and supporting films, cells and adjacent cells, films and surrounding media, and other cross-reactions, with particular attention to technology that may control these interactions to either promote or prevent bioadhesion in practical biomedical or bioengineering situations; and 4) Scale- up of these biotechnologies to macrosystem processes, like adhesive secretion or biomineralization, that may produce new, or mimic existing, materials such as structural composite shells and adhesives of natural organisms. This multi-site Center has been coordinated with Dr. Norman Caplan, Program Director, Environmental Systems Program. The State University of New York has requested funding to support undergraduate research assistants. These students will participate in the Center's ongoing research projects. Additional funding is provided through a supplemental Research Opportunity Award (ROA) for a woman Assistant Professor at D'Youville College to perform research for the State University of New - Buffalo. Pa ge 1 of 2 The Project is determining the protein structure associated with bioadhesives functionality. The project's goal is to study the protein structures responsible for the binding ability of selected native adhesive protein domains and for their use in the development of manufactured proteinaceous adhesive agents. The Program Manager recommends the State University of New York at Buffalo be awarded: $50,000 for the first year of a five-year continuing award (including $25,000 for administrative activities); $50,000 for the first year of a five-year continuing award to the University of Memphis through a subcontract; $50,000 for the first year of a five-year continuing award to the New York State College of Ceramics through a subcontract; $5,000 for one year with funds provided by the Women, Minorities, and Disabled Engineering Research Assistants Program; and $54,995 for 24 months for a Research Opportunity award. Near the end of each 12-month period the Program Manager and/or the Division Director of the Engineering Education Centers Division will review the progress of the Center on a number of renewal criteria requirements, including the following: 1) the extent to which the industry/university interaction is developing; 2) the extent to which support base is developing; and 3) the extent to which a robust research program is developing. If the review is satisfactory, the Program Manager will recommend support for the next period of this continuing award. Page 2 of 2