Design of New Helical Metal Ligand Systems for Asymmetric Catalysis

9418360沃尔什这项授予圣地亚哥州立大学的初学者奖金将支持帕特里克·沃尔什教授的研究。本研究的目标是开发新型手性金属配合物，并将其应用于有机合成催化剂。具体地说，将制备基于磺酰胺取代的手性二胺的配体，当它们与IV族金属结合时将形成四面体螺旋络合物。这些强酸性络合物将作为催化剂在Diels-Alder反应、Claisen重排和Aldol缩合反应中作为碳-碳键形成活性进行测试。这种不对称催化和分子识别的研究将推动手性路易斯酸催化研究的进展。新的配体络合物将是通用的，并将在有机合成中使用。

9418360 Walsh This starter grant award to San Diego State University will support the research of Professor Patrick Walsh. The goal of the research is the development of new chiral metal complexes and their application as catalysts for organic synthesis. Specifically, ligands based on sulfonamide-substituted chiral diamines will be prepared which will form tetrahedral helical complexes when combined with Group IV metals. These strongly acidic complexes will be tested as catalyts for carbon-carbon bond formation activity in the Diels-Alder reaction, the Claisen rearrangement and aldol condensations. This study of asymmetric catalysis and molecular recognition will lead to advances in chiral Lewis acid catalysis. The new ligand complexes will be versatile and will be of general use in organic synthesis.