Biomimetic and Enzyme Investigations of Haloperoxides

该奖项在无机，生物无机和有机化学 该计划支持化学部的艾莉森·巴特勒博士的研究 加州大学圣巴巴拉分校海洋系 卤素过氧化物酶 钒溴过氧化物酶和 铁血红素溴过氧化物酶，包括它们在生物合成中的作用，将是 研究使用功能模型复合物和酶的研究。 α-螺旋肽的钒络合物和α-螺旋肽 与钒卤代过氧化物酶非常相似的纤维束将被 合成并测试。 此外，一些新的介孔和钛 将制备二氧化物材料并测试其过氧化性。 卤化反应性 反应性比较将进行海洋 从手性卤代乙酸配基中分离的卤代过氧化物， 从海藻中提取的倍半萜。 的卤化物选择性。 来自藻类的钒卤代过氧化物酶， 将对溴化烃进行调查。 许多海洋天然产物和酶具有重要的工业价值 在特种化学品、诊断、制药和 生物技术产业。 发展使用其中一些 天然产品由于缺乏足够的 是介于 这项工作将确定一些海洋功能模拟 存在于海藻中的卤代过氧化物酶。 这些化合物具有潜在的 用作生产氧化剂和卤化剂的催化剂， 这些工艺将是对环境有益的替代品， 现在的技术。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry program supports research by Dr. Alison Butler of the Chemistry Department, University of California at Santa Barbara, on marine haloperoxidase enzymes. The reactivities of vanadium bromoperoxidase and FeHeme bromoperoxidase, including their roles in biosynthesis, will be investigated using functional model complexes and enzyme studies. Vanadium complexes of alpha-helical peptides and alpha-helical peptide bundles that closely resemble vanadium haloperoxidases will be synthesized and tested. In addition some new mesoporous and titanium dioxide materials will be prepared and tested for peroxidative halogenation reactivity. Reactivity comparisons will be made to marine haloperoxides isolated from chiral halogenated acetogenins and sesquiterpenes produced from marine algae. The halide selectivity of vanadium haloperoxidases from algae that evolve chlorinated and brominated hydrocarbons will be investigated. Many marine natural products and enzymes have important industrial applications in the specialty chemical, diagnostics, pharmaceutical, and biotechnology industries. Development of the use of some of these natural products has been inhibited by lack of availability of sufficient quantities. This work will identify functional mimics for some marine haloperoxidases present in marine algae. These compounds have potential use as catalysts for production of oxidants and halogenating agents in situ, processes that would be environmentally beneficial alternatives to present technology.