Upgrade of 500 MHz Console

这份来自化学研究仪器和设施项目的合同将帮助俄亥俄州立大学化学系升级现有500 MHz核磁共振光谱仪的控制台。该设备将加强许多领域的研究，包括：(1)肿瘤抑制因子的结构-功能关系，(2)穿孔素介导的细胞溶解，(3)维生素a及其代谢物的化学和生物化学，(4)离子配对过渡态反应，(5)无机氧化玻璃的结构/性质关系，(6)糖苷酶抑制剂的核磁共振构象研究，以及(7)蛋白质中的紧密结构域。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将在聚合物、催化和生物学等领域有用。

This award from the Chemistry Research Instrumentation and Facilities Program will assist the Department of Chemistry at Ohio State University to acquire an upgrade of the console of an existing 500 MHz NMR spectrometer. This equipment will enhance research in a number of areas including the following: (1) The structure-function relationship of tumor suppressors, (2) Perforin-mediated cytolysis, (3) Chemistry and biochemistry of Vitamin A and its metabolites, (4) Reactions via ion-paired transition states, (5) Structure/property relationships in inorganic oxide glasses, (6) NMR conformational studies of glycosidase inhibitors, and (7) Compact domains in proteins. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will be useful in areas such as polymers, catalysis, and biology.